Extraversion Is Associated With Lower Brain Beta-Amyloid Deposition in Cognitively Normal Older Adults.
Extraversion Is Associated With Lower Brain Beta-Amyloid Deposition in Cognitively Normal Older Adults.
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DOI：
10.3389/fnagi.2022.900581
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发表时间：
2022
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
新出现的证据表明，某些性格特征可能与阿尔茨海默病 (AD) 的易感性或预防相关。然而，这种关系背后的因果机制仍然很大程度上未知。利用 18F-Florbetaben 正电子发射断层扫描 (PET) 与 β-淀粉样蛋白 (Aβ) 斑块（AD 的病理特征）结合以及功能磁共振成像 (fMRI)，我们研究了一组健康年轻和老年受试者的外向性和神经质的病理和功能相关性。我们量化了老年人大脑 Aβ 沉积的水平。使用任务切换功能磁共振成像范式测量年轻人的大脑活动。当我们将外向性和神经质的人格得分与这些病理和功能测量相关联时，考虑到年龄和性别，较高的外向性（而不是神经质）与老年人中较低的总体 Aβ 测量值显着相关。这种关联存在于广泛的大脑区域。在年轻受试者中，较高的外向性与前扣带皮层、左前岛叶皮层、左壳核和双侧额中回任务切换期间的较低活动相关，而较高的神经质则与整个大脑的活动增加相关。目前的结果表明，外向性（终生人格特征之一）可能通过有效的神经元活动，提供针对衰老过程中 Aβ 病理发展的保护机制。
Emerging evidence suggests that some personality traits may link to the vulnerability to or protection for Alzheimer’s disease (AD). A causal mechanism underlying this relationship, however, remains largely unknown. Using 18F-Florbetaben positron emission tomography (PET) binding to beta-amyloid (Aβ) plaques, a pathological feature of AD, and functional magnetic resonance imaging (fMRI), we investigated pathological and functional correlates of extraversion and neuroticism in a group of healthy young and older subjects. We quantified the level of brain Aβ deposition in older individuals. Brain activity was measured in young adults using a task-switching fMRI paradigm. When we correlated personality scores of extraversion and neuroticism with these pathological and functional measures, higher extraversion, but not neuroticism, was significantly associated with lower global Aβ measures among older adults, accounting for age and sex. This association was present across widespread brain regions. Among young subjects, higher extraversion was associated with lower activity during task switching in the anterior cingulate cortex, left anterior insular cortex, left putamen, and middle frontal gyrus bilaterally, while higher neuroticism was associated with increased activity throughout the brain. The present results suggest that possibly via efficient neuronal activity, extraversion, one of the lifelong personality traits, may confer the protective mechanism against the development of Aβ pathology during aging.
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影响因子：
16.2
作者：
Kamenetz, F;Tomita, T;Malinow, R
通讯作者：
Malinow, R
影响因子：
19.9
作者：
Jagust, William J.;Mormino, Elizabeth C.
通讯作者：
Mormino, Elizabeth C.
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
4.8
作者：
Kapogiannis, Dimitrios;Sutin, Angelina;Davatzikos, Christos;Costa, Paul, Jr.;Resnick, Susan
通讯作者：
Resnick, Susan
影响因子：
15.1
作者：
Fisher JR;Wallace CE;Tripoli DL;Sheline YI;Cirrito JR
通讯作者：
Cirrito JR