The five factors of personality and regional cortical variability in the Baltimore longitudinal study of aging.
The five factors of personality and regional cortical variability in the Baltimore longitudinal study of aging.
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DOI：
10.1002/hbm.22108
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发表时间：
2013-11
影响因子：
4.8
通讯作者：
Resnick, Susan
中科院分区：
文献类型：
--
作者：
Kapogiannis, Dimitrios;Sutin, Angelina;Davatzikos, Christos;Costa, Paul, Jr.;Resnick, Susan
关键词：
虽然人格改变与神经退行性疾病和衰老引起的脑损伤和萎缩有关，但健康个体的人格及其随时间的稳定性的神经解剖学相关性却相对较少。在这项研究中，我们探讨了区域灰质（GM）体积协会的五因素人格模型。87名健康的老年人接受了NEO人格量表，并在相隔2年的两个时间点进行了大脑MRI。我们进行GM分割，然后在SPM 8中对标准化空间图创建和基于体素的形态测量型统计推断中检查的体积进行区域分析。我们建立了一个回归模型，包括所有五个因素和重要的协变量。接下来，一个关联分析确定了人格分数和GM卷之间的关联，这些关联在一段时间内是可复制的，也使用了集群级别的Family-Wise-Error校正。较大的右眶额和背外侧前额叶皮质以及rolandic岛盖与较低的神经质相关;较大的左颞叶、背外侧前额叶和前扣带回皮质与较高的外倾性相关;较大的右额极和较小的眶额和岛叶皮质与较高的开放性相关;较大的右眶额皮质与较高的易混淆性相关;较大的背外侧前额叶和较小的额极皮质与较高的责任心相关。总之，不同的人格特质与GM体积的稳定个体差异相关。正如预期的高阶性状，区域执行大量的认知和情感功能的牵连。我们的研究结果突出了个性相关的变化，可能与大脑结构的个体差异有关，值得在神经影像学研究中给予额外的关注。
Although personality changes have been associated with brain lesions and atrophy caused by neurodegenerative diseases and aging, neuroanatomical correlates of personality in healthy individuals and their stability over time have received relatively little investigation. In this study, we explored regional gray matter (GM) volumetric associations of the five-factor model of personality. Eighty-seven healthy older adults took the NEO Personality Inventory and had brain MRI at two time points 2 years apart. We performed GM segmentation followed by regional analysis of volumes examined in normalized space map creation and voxel based morphometry-type statistical inference in SPM8. We created a regression model including all five factors and important covariates. Next, a conjunction analysis identified associations between personality scores and GM volumes that were replicable across time, also using cluster-level Family-Wise-Error correction. Larger right orbitofrontal and dorsolateral prefrontal cortices and rolandic operculum were associated with lower Neuroticism; larger left temporal, dorsolateral prefrontal, and anterior cingulate cortices with higher Extraversion; larger right frontopolar and smaller orbitofrontal and insular cortices with higher Openness; larger right orbitofrontal cortex with higher Agreeableness; larger dorsolateral prefrontal and smaller frontopolar cortices with higher Conscientiousness. In summary, distinct personality traits were associated with stable individual differences in GM volumes. As expected for higher-order traits, regions performing a large number of cognitive and affective functions were implicated. Our findings highlight personality-related variation that may be related to individual differences in brain structure that merit additional attention in neuroimaging research.
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