Different Roles of the Left and Right Ventrolateral Prefrontal Cortex in Cognitive Reappraisal: An Online Transcranial Magnetic Stimulation Study.
Different Roles of the Left and Right Ventrolateral Prefrontal Cortex in Cognitive Reappraisal: An Online Transcranial Magnetic Stimulation Study.
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DOI：
10.3389/fnhum.2022.928077
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发表时间：
2022
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
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腹外侧额叶皮质(VLPFC)在认知再评价中起着关键作用。以往的研究表明双侧VLPFC存在功能不对称，但在认知再评估中证据仍然不足。在这项研究中，我们进行了在线单脉冲经颅磁刺激(SpTMS)，以探讨左侧和右侧VLPFC在重新评估中的因果和不同作用。参与者被指示重新评估(下调)或注意描述社会排斥情景的图片，同时将spTMS应用于参与者大脑的左侧或右侧VLPFC。结果表明，无论是左侧还是右侧VLPFC的SPTMS都会增加再评价的难度。同时，当SPTMS短暂中断右侧(而不是左侧)VLPFC时，重评结果(以自我报告的负面情绪测量)显著恶化，而当左侧VLPFC被SPTMS中断时，口头报告重评策略的语言流畅性显著降低。综上所述，这些发现为左右两个不同角色的VLPFC的参与提供了因果证据：左侧VLPFC负责根据情绪调节目标生成和选择评价的语言过程，特别是语义过程，而右侧VLPFC在抑制有效情景产生的不适当的负面情绪和思想方面起着关键作用。这些发现加深了我们对情绪调节的神经认知机制的理解。
The ventrolateral prefrontal cortex (VLPFC) plays a pivotal role in cognitive reappraisal. Previous studies suggested a functional asymmetry of the bilateral VLPFC, but the evidence is still insufficient during cognitive reappraisal. In this study, we conducted an online single-pulse transcranial magnetic stimulation (spTMS) to investigate the causal and distinct roles of the left and right VLPFC in reappraisal. Participants were instructed to reappraise (down-regulate) or attend to pictures depicting social exclusion scenarios while the spTMS was applied over the left or right VLPFC of the participants’ brains. The results showed that spTMS of either the left or the right VLPFC would increase reappraisal difficulty. Meanwhile, the outcome of reappraisal (measured by self-reported negative feelings) significantly deteriorated when the right (but not the left) VLPFC was temporally interrupted by spTMS, while the verbal fluency during oral reporting of the reappraisal strategy was significantly reduced when the left VLPFC was interrupted by spTMS. Taken together, these findings provide causal evidence for the involvement of left and right VLPFC with distinct roles: while the left VLPFC is responsible for the linguistic especially semantic process of generating and selecting appraisals according to the goal of emotion regulation, the right VLPFC plays a critical role in inhibiting inappropriate negative emotions and thoughts generated by the effective scenarios. These findings deepen our understanding of the neurocognitive mechanism of emotion regulation.
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DOI：
10.1016/j.nicl.2021.102702
发表时间：
2021
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Banjac S;Roger E;Pichat C;Cousin E;Mosca C;Lamalle L;Krainik A;Kahane P;Baciu M
通讯作者：
Baciu M
影响因子：
4.7
作者：
Keller M;Zweerings J;Klasen M;Zvyagintsev M;Iglesias J;Mendoza Quiñones R;Mathiak K
通讯作者：
Mathiak K
影响因子：
3.7
作者：
Buhle, Jason T.;Silvers, Jennifer A.;Ochsner, Kevin N.
通讯作者：
Ochsner, Kevin N.
影响因子：
5.3
作者：
Leung, Hoi-Chung;Cai, Weidong
通讯作者：
Cai, Weidong
影响因子：
4.5
作者：
Kaladjian, Arthur;Jeanningros, Regine;Mazzola-Pomietto, Pascale
通讯作者：
Mazzola-Pomietto, Pascale