Vitamin E Ameliorates Impaired Ovarian Development, Oxidative Stress, and Disrupted Lipid Metabolism in Oreochromis niloticus Fed with a Diet Containing Olive Oil Instead of Fish Oil.
Vitamin E Ameliorates Impaired Ovarian Development, Oxidative Stress, and Disrupted Lipid Metabolism in Oreochromis niloticus Fed with a Diet Containing Olive Oil Instead of Fish Oil.
复制标题
DOI：
10.3390/antiox12081524
复制
发表时间：
2023-07-29
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
含有橄榄油（OO）而不是鱼油（FO）的水产饲料会导致鱼类氧化应激，损害性腺发育。我们确定了饮食OO诱导的氧化应激对卵巢发育的影响，并探讨了维生素E（VE）是否可以减轻负面影响。用5% OO + 70 mg/kg VE、5% OO + 200 mg/kg VE、5% FO + 70 mg/kg VE和5% FO +200 mg/kg VE 4种饲料饲喂雌性尼罗罗非鱼10周。日粮OO降低特定生长率和性腺指数，抑制超氧化物歧化酶和过氧化氢酶，延迟卵巢发育，降低血清性激素水平，降低卵巢甘油三酯和n-3高度不饱和脂肪酸含量。编码性激素受体（erα、fshr、lhr）和脂质代谢途径组分（pparα、pparγ、hsl、accα、elovl 6）、nrf 2信号途径（nrf 2、keap 1）和nf-κB信号途径（nf-κB、tnfα、infγ、il 1 β）的基因的转录水平在70 VE/OO和70 VE/FO组之间不同。补充200 mg/kg VE可通过提高机体抗氧化能力、减轻炎症反应和脂质代谢异常来减轻OO的不良影响。这可能是因为VE是一种抗氧化剂，它可以调节nrf 2-nf-κB信号通路。
Aquaculture feed containing olive oil (OO) instead of fish oil (FO) can cause oxidative stress and impair gonad development in fish. We determined the effect of dietary OO-induced oxidative stress on ovarian development, and explored whether vitamin E (VE) could mitigate negative effects. Female Nile tilapia (Oreochromis niloticus) were fed for 10 weeks with four diets: 5% OO + 70 mg/kg VE, 5% OO + 200 mg/kg VE, 5% FO + 70 mg/kg VE, or 5% FO + 200 mg/kg VE. Dietary OO reduced the specific growth rate and gonadosomatic index, inhibited superoxide dismutase and catalase, delayed ovarian development, decreased serum sex hormone levels, and reduced ovarian triglyceride and n-3 highly unsaturated fatty acid contents. The transcript levels of genes encoding sex hormone receptors (erα, fshr, lhr) and components of the lipid metabolism pathway (pparα, pparγ, hsl, accα, elovl6), the nrf2 signaling pathway (nrf2, keap1), and the nf-κb signaling pathway (nf-κb, tnfα, infγ, il1β) differed between the 70VE/OO and 70VE/FO groups. Supplementation with 200 mg/kg VE mitigated the adverse effects of OO by improving antioxidant capacity and alleviating inflammation and abnormal lipid metabolism. This may be because VE is an antioxidant and it can regulate the nrf2-nf-κb signaling pathway.
登录
查看更多内容
影响因子：
5.6
作者：
Zhuo MQ;Luo Z;Xu YH;Li DD;Pan YX;Wu K
通讯作者：
Wu K
影响因子：
8.7
作者：
Dinarello CA
通讯作者：
Dinarello CA
影响因子：
8.8
作者：
Alhazzaa, Ramez;Bridle, Andrew R.;Carter, Chris G.
通讯作者：
Carter, Chris G.
影响因子：
2.9
作者：
Cheng, Chang-Hong;Guo, Zhi-Xun;Wang, An-Li
通讯作者：
Wang, An-Li
DOI：
10.1016/j.cbpb.2017.03.005
发表时间：
2017-06-01
影响因子：
2.2
作者：
Johnson, Ronald B.;Kroeger, Eric L.;Rust, Michael B.
通讯作者：
Rust, Michael B.