Obstructive Sleep Apnea is Associated with Longitudinal Increases in Amyloid Burden in Elderly Mild Cognitive Impairment Individuals
Obstructive Sleep Apnea is Associated with Longitudinal Increases in Amyloid Burden in Elderly Mild Cognitive Impairment Individuals
复制标题
阻塞性睡眠呼吸暂停与老年轻度认知障碍患者淀粉样蛋白负荷的纵向增加有关
DOI：
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
O. Bubu
中科院分区：
文献类型：
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作者：
Megan M Hogan;Amanda Shim;O. Umasabor;Mukhtar Fahad;O. Bubu
横断面分析显示，轻度认知功能障碍（MCI）患者中，使用淀粉样蛋白PET的阻塞性睡眠呼吸暂停（OSA）严重程度与A β负荷之间存在相关性。然而，OSA是否加速MCI患者中淀粉样蛋白β（A β）负荷的纵向增加目前尚不清楚。研究参与者包括总共798名被诊断为MCI的受试者，并且是ADNI队列的子集（www.example.com）。OSA是自我报告的，参与者被标记为OSA+或OSA −。通过florbetapir SUVR测定A β负荷。为了检验OSA是否与A β数据的纵向变化率相关，使用多水平混合效应线性回归拟合模型，其中随机变化的截距和斜率允许依赖于OSA状态。最终模型根据年龄、性别、体重指数、教育程度、CPAP使用状况、呼吸系统疾病史、高血压、糖尿病和心血管疾病史进行调整。观察到A β体积随时间变化（斜率）的显著变化（p <.0001）。基线A β水平和A β体积随时间变化之间的协方差表明，OSA受试者的脑A β体积随时间变化的平均差异更大（p <.0001）。在随访期间，OSA组之间A β沉积的变化率也存在显著差异。阻塞性睡眠呼吸暂停可能促进老年轻度认知障碍患者淀粉样蛋白负荷的纵向增加。需要进一步研究OSA对A β负荷纵向增加的潜在影响机制。
Cross sectional analysis has shown an association between Obstructive Sleep Apnea (OSA) severity and Aβ burden using amyloid-PET among Mild Cognitive Impairment (MCI) patients. However, whether OSA accelerates longitudinal increases in amyloid beta (Aβ) burden in MCI patients is presently unclear. Study participants included a total of 798 subjects with a diagnosis of MCI and were a subset of the ADNI cohort (adni.loni.usc.edu). OSA was self-reported and participants were labeled either as OSA+ or OSA−. Aβ burden was determined by florbetapir SUVRs. To test whether OSA is associated with the rate of change in Aβ data longitudinally, multilevel mixed effects linear regression was used to fit the models with randomly varying intercepts and slopes allowing dependence on OSA status. The final model was adjusted for age, sex, body mass index, education, CPAP use status, history of respiratory disease, hypertension, diabetes, and history of cardiovascular disease. A significant variation in the change (slope) in Aβ volumes over time was seen (p<.0001). The covariance between the baseline Aβ level and Aβ volume change over time indicated that OSA subjects experienced greater mean change differences in brain Aβ volumes over time (p < .0001). The rate of change in Aβ deposition also varied significantly across OSA groups over the follow-up period. Obstructive Sleep Apnea possibly facilitates longitudinal increases in amyloid burden in elderly Mild Cognitive Impairment individuals. Further research examining mechanisms underlying effects of OSA on the longitudinal increases in Aβ burden is needed.
影响因子：
158.5
作者：
YOUNG, T;PALTA, M;BADR, S
通讯作者：
BADR, S
睡眠质量和临床前阿尔茨海默氏病。
影响因子：
29
作者：
Ju, Yo-El S.;McLeland, Jennifer S.;Toedebusch, Cristina D.;Xiong, Chengjie;Fagan, Anne M.;Duntley, Stephen P.;Morris, John C.;Holtzman, David M.
通讯作者：
Holtzman, David M.
影响因子：
29
作者：
Spira, Adam P.;Gamaldo, Alyssa A.;An, Yang;Wu, Mark N.;Simonsick, Eleanor M.;Bilgel, Murat;Zhou, Yun;Wong, Dean F.;Ferrucci, Luigi;Resnick, Susan M.
通讯作者：
Resnick, Susan M.