Diverse and dynamic sources and sinks in gradient formation and directed migration.
Diverse and dynamic sources and sinks in gradient formation and directed migration.
复制标题
梯度形成和定向迁移的多样和动态来源和下沉。
DOI：
10.1016/j.ceb.2014.06.009
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发表时间：
2014-10
影响因子：
7.5
通讯作者：
Montell, Denise J.
中科院分区：
文献类型：
--
作者：
Cai, Danfeng;Montell, Denise J.
组织内定向细胞迁移的传统观点是，它需要可溶性有吸引力的化学物质的梯度，由于源和汇的存在，该化学物质在空间和时间上是稳定的。然而，实时成像技术的进步和研究体内细胞迁移的能力表明，内源性来源和汇通常更加多样化和复杂。源和汇都可以由多个组织组成。在长距离迁移过程中，细胞倾向于划分其轨迹，并在每个部分遵循不同的源信号。当在每个段中重复使用单个源信号时，其表达是动态控制的。源信号也可以本地源自邻近的迁移细胞。在某些情况下，汇很重要，但不是在所有情况下，它可以塑造一条允许的迁移路径或允许细胞从一个中间目标移动到另一个目标。迁移细胞本身可以充当汇，从最初均匀的趋化剂中产生梯度。这些构建源和库的不同方式允许不同的细胞类型在同一胚胎中导航不同的轨迹，即使整个胚胎经历细胞数量、位置、排列和命运的巨大变化，这是发育的本质。
The traditional view of directional cell migration within a tissue is that it requires a gradient of a soluble attractive chemical that is stable in space and time due to the presence of a source and a sink. However, advances in live imaging technology and the ability to study cell migration in vivo have revealed that endogenous sources and sinks are typically far more varied and complex. Both sources and sinks can be made up of multiple tissues. During long-range migrations, cells tend to divide up their trajectories and follow different source signals in each segment. When a single source signal is used repeatedly in each segment, its expression is dynamically controlled. Source signals can also originate locally from neighboring migrating cells. Sinks are important in some cases but not all, to sculpt a permissive migratory path or allow cells to move from one internediate target to another. Migrating cells themselves can function as sinks to create a gradient out of an initially uniform chemoattractant. These diverse ways of building sources and sinks allow different cell types to navigate distinct trajectories through the same embryo even as the whole embryo undergoes the dramatic changes in cell number, position, arrangement and fate that are the essence of development.
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影响因子：
4.6
作者：
Renault, Andrew D.;Kunwar, Prabhat S.;Lehmann, Ruth
通讯作者：
Lehmann, Ruth
影响因子：
11.8
作者：
Reichman-Fried, M;Minina, S;Raz, E
通讯作者：
Raz, E
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1039/c2ib00106c
发表时间：
2012-03
期刊：
Integrative biology : quantitative biosciences from nano to macro
影响因子：
--
作者：
Scherber C;Aranyosi AJ;Kulemann B;Thayer SP;Toner M;Iliopoulos O;Irimia D
通讯作者：
Irimia D
影响因子：
2.7
作者：
Soll, DR;Wessels, D;Zhang, H
通讯作者：
Zhang, H