Semantic clustering and sleep in patients with amnestic mild cognitive impairment or with vascular cognitive impairment-no dementia
Semantic clustering and sleep in patients with amnestic mild cognitive impairment or with vascular cognitive impairment-no dementia
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遗忘性轻度认知障碍或血管性认知障碍（无痴呆）患者的语义聚类和睡眠
DOI：
10.1017/s1041610216000739
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发表时间：
2016-05
影响因子：
7
通讯作者：
Zhang Nan
中科院分区：
文献类型：
--
作者：
Sun Qingna;Luo Lanlan;Ren Honglei;Wei Changjuan;Xing Mengya;Cheng Yan;Zhang Nan
摘要背景：认知和睡眠缺陷发生在遗忘型轻度认知障碍（aMCI）和血管性认知障碍-非痴呆（VCIND）中。然而，记忆和睡眠缺陷在aMCI和VCIND之间的差异仍不清楚。研究方法：对50名aMCI和50名VCIND患者以及38名性别和年龄匹配的健康对照（HC）进行霍普金斯言语学习测试-修订版（HVLT-R）、连线测试-A/B（TMT-A/B）、威斯康星州卡片分类测试（WCST）、起搏听觉序列加法测试（PASAT）、符号数字模态测试（SDMT）、本顿直线方向判断（JLO）测试、匹兹堡睡眠质量指数（PSQI）、埃普沃思嗜睡量表（ESS）和失眠严重程度指数（ISI），以量化认知缺陷和主观睡眠障碍。结果如下：与VCIND患者相比，aMCI患者的总回忆（p < 0.001）、延迟回忆（p <0.001）和识别（p = 0.001）以及总回忆（p = 0.002）和延迟回忆（p < 0.001）语义聚类比率（SCR）的HVLT-R评分较低。而VCIND患者的执行功能障碍更为明显（TMT-A，p < 0.001; TMT-B，p < 0.001; WCST，p < 0.001），较低的信息处理速度（PASAT，p = 0.003; SDMT，p < 0.001），和更严重的睡眠障碍（PSQI，p < 0.001; ESS，p < 0.001; ISI，p < 0.001）。此外，在aMCI和VCIND中，睡眠质量和效率与总回忆和延迟回忆相关（所有r值均为-0.31至-0.60，p < 0.05）。结论：aMCI和VCIND在认知功能、记忆策略和睡眠障碍方面存在差异，这些特征有助于识别和区分极早期认知障碍患者。我们的研究结果还表明，记忆缺陷与aMCI和VCIND的睡眠障碍有关。
ABSTRACT Background: Cognition and sleep deficits occur in amnestic mild cognitive impairment (aMCI) and vascular cognitive impairment-no dementia (VCIND). However, how memory and sleep deficits differ between aMCI and VCIND remains unclear. Methods: Fifty aMCI and 50 VCIND patients and 38 sex- and age-matched healthy controls (HCs) were administered the Hopkins Verbal Learning Test-Revised (HVLT-R), Trail Making Test-A/B (TMT-A/B), Wisconsin Card Sorting Test (WCST), Paced Auditory Serial Addition Test (PASAT), Symbol Digit Modalities Test (SDMT), Benton Judgment of Line Orientation (JLO) test, Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and Insomnia Severity Index (ISI) to quantify cognitive deficits and subjective sleep disturbance. Results: Compared with VCIND patients, aMCI patients had lower HVLT-R scores for total recall (p < 0.001), delayed recall (p < 0.001) and recognition (p = 0.001), and for total-recall (p = 0.002) and delayed-recall (p < 0.001) semantic clustering ratios (SCRs). However, VCIND patients exhibited more obvious executive dysfunction (TMT-A, p < 0.001; TMT-B, p < 0.001; WCST, p < 0.001), lower information processing speed (PASAT, p = 0.003; SDMT, p < 0.001), and more severe sleep disturbance (PSQI, p < 0.001; ESS, p < 0.001; ISI, p < 0.001). Additionally, sleep quality and efficiency were related to total and delayed recall (all r values from −0.31 to −0.60, p < 0.05) in aMCI and VCIND. Conclusions: aMCI and VCIND differ in cognitive function, memory strategy and sleep impairment; these characteristics are helpful to identify and distinguish patients with very early cognitive impairment. Our results also suggest that memory deficits are associated with sleep disturbance in aMCI and VCIND.
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DOI：
10.1007/978-3-030-49586-2_6
发表时间：
2020
期刊：
Neurovascular Neuropsychology
影响因子：
--
作者：
P. B. Gorelick
通讯作者：
P. B. Gorelick
影响因子：
11
作者：
Bowler, JV
通讯作者：
Bowler, JV
DOI：
10.1017/9781108587921.004
发表时间：
2008-11
期刊：
Language in Dementia
影响因子：
--
作者：
Li Qiang
通讯作者：
Li Qiang
DOI：
10.1212/con.0000000000000304
发表时间：
2016-04
期刊：
CONTINUUM: Lifelong Learning in Neurology
影响因子：
--
作者：
Eric D. Smith
通讯作者：
Eric D. Smith
DOI：
10.1093/med/9780199937837.003.0021
发表时间：
2017
期刊：
--
影响因子：
--
作者：
Elka Stefanova;Vladimir S. Kostić
通讯作者：
Elka Stefanova;Vladimir S. Kostić