Diabetes and breast cancer among women with BRCA1 and BRCA2 mutations.
Diabetes and breast cancer among women with BRCA1 and BRCA2 mutations.
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DOI：
10.1002/cncr.25595
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发表时间：
2011-05-01
期刊：
影响因子：
6.2
通讯作者：
Narod, Steven A.
中科院分区：
文献类型：
--
作者：
Bordeleau, Louise;Lipscombe, Lorraine;Lubinski, Jan;Ghadirian, Parviz;Foulkes, William D.;Neuhausen, Susan;Ainsworth, Peter;Pollak, Michael;Sun, Ping;Narod, Steven A.
高胰岛素血症和代谢综合征都是乳腺癌的危险因素。目前尚不清楚糖尿病是否与BRCA1或BRCA2突变女性患乳腺癌的风险有关。作者回顾了6052名BRCA1或BRCA2突变女性的病史，其中一半被诊断为乳腺癌。考虑到糖尿病的自我报告，他们估计了乳腺癌的赔率比。然后，他们估计了新诊断的与乳腺癌病史相关的糖尿病的风险比。与没有诊断出乳腺癌的对照组相比，在乳腺癌诊断之前的一段时间内没有过量的糖尿病。在诊断为乳腺癌后的15年间，BRCA携带者患糖尿病的风险是非乳腺癌携带者的两倍(相对风险，2.0；95%可信区间[CI]，1.4-2.8；P=0.0001)。对于体重指数(BMI)为25.0 kg/m2的女性来说，风险尤其高(优势比为5.8；95%可信区间为4.0-8.6；P=0.0001)。在诊断出乳腺癌后，携带BRCA1或BRCA2突变的女性患糖尿病的风险增加了2倍，而高BMI会加剧糖尿病的风险。
Hyperinsulinemia and the metabolic syndrome are both risk factors for breast cancer. It is not clear if diabetes is associated with the risk of breast cancer in women with a BRCA1 or BRCA2 mutation. The authors reviewed the medical histories of 6052 women with a BRCA1 or BRCA2 mutation, half of whom had been diagnosed with breast cancer. They estimated the odds ratio for breast cancer, given a self-report of diabetes. They then estimated the hazard ratio for a new diagnosis of diabetes associated with a history of breast cancer. There was no excess of diabetes in the period before the diagnosis of breast cancer, compared with controls with no diagnosis of breast cancer. The risk of diabetes was doubled among BRCA carriers in the 15-year period after the diagnosis of breast cancer (relative risk, 2.0; 95% confidence interval [CI], 1.4–2.8; P = .0001), compared with carriers without cancer. The risk was particularly high for women with a body mass index (BMI) >25.0 kg/m2 (odds ratio, 5.8; 95% CI, 4.0–8.6; P = .0001). After a diagnosis of breast cancer, women with a BRCA1 or BRCA2 mutation face a 2-fold increase in the risk of diabetes, which is exacerbated by a high BMI.
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影响因子：
3.8
作者：
Keegan, Theresa H. M.;Milne, Roger L.;Andrulis, Irene L.;Chang, Ellen T.;Sangaramoorthy, Meera;Phillips, Kelly-Anne;Giles, Graham G.;Goodwin, Pamela J.;Apicella, Carmel;Hopper, John L.;Whittemore, Alice S.;John, Esther M.
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影响因子：
45.3
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通讯作者：
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影响因子：
4.2
作者：
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通讯作者：
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