Combination of conjugated linoleic acid with fish oil prevents age-associated bone marrow adiposity in C57Bl/6J mice.
Combination of conjugated linoleic acid with fish oil prevents age-associated bone marrow adiposity in C57Bl/6J mice.
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DOI：
10.1016/j.jnutbio.2010.03.015
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发表时间：
2011-05
影响因子：
5.6
通讯作者：
Fernandes, Gabriel
中科院分区：
文献类型：
--
作者：
Halade, Ganesh V.;Rahman, Md M.;Williams, Paul J.;Fernandes, Gabriel
众所周知，衰老受试者骨髓中的脂肪与骨骼中的骨量之间存在相反的关系。然而，目前还没有精确的治疗方法来治疗骨髓肥胖症。以饲喂10%玉米油(CO)的12月龄C57BL/6J小鼠为对照，分别添加0.5%CLA、5%FO或0.5%CLA+5%FO 6个月，研究共轭亚油酸(CLA)和鱼油(FO)单独或联合作用对骨丢失的调节作用。我们发现，CLA喂养的小鼠体重、体脂质量(BFM)降低，DXA测量的不同部位的后腿瘦质量(HLLM)和骨密度(BMD)增加，但与脂肪肝和胰岛素抵抗增加相关；而FO喂养的小鼠表现出骨密度增加，胰岛素敏感性改善，而BFM和HLLM没有变化。有趣的是，CLA+FO喂养的小鼠体重、骨密度、骨髓中PPARγ和组织蛋白酶K的表达降低，骨密度和hLLm增加。此外，补充CLA+FO可减轻衰老小鼠的肝脏肥大，改善胰岛素敏感性，并显著减轻骨髓肥大、炎症和氧化应激。因此，CLA与FO联合应用可能成为一种新型的减肥、改善骨密度的膳食补充方案。
The inverse relationship between fat in bone marrow and bone mass in the skeleton of aging subjects is well-known. However, there is no precise therapy for the treatment of bone marrow adiposity. We investigated the ability of conjugated linoleic acid (CLA) and fish oil (FO), alone or in combination, to modulate bone loss using 12 months old C57Bl/6J mice fed 10% corn oil (CO) diet as control or supplemented with 0.5% CLA or 5% FO or 0.5% CLA+5% FO for 6 months. We found, CLA fed mice exhibited reduced body weight, body fat mass (BFM), and enhanced hind leg lean mass (HLLM) and bone mineral density (BMD) in different regions measured by DXA; however, associated with fatty liver and increased insulin resistance; whereas, FO fed mice exhibited enhanced BMD, improved insulin sensitivity, with no changes in BFM and HLLM. Interestingly, CLA+FO fed mice exhibited reduced body weight, BFM, PPARγ and cathepsin K expression in bone marrow with enhanced BMD and HLLM. Moreover, CLA+FO supplementation reduced liver hypertrophy and improved insulin sensitivity with remarkable attenuation of bone marrow adiposity, inflammation and oxidative stress in aging mice. Therefore, CLA with FO combination might be a novel dietary supplement to reduce fat mass and improve BMD.
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影响因子：
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