Circadian disruption and SCN control of energy metabolism.

Circadian disruption and SCN control of energy metabolism.
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DOI:
10.1016/j.febslet.2011.03.021
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发表时间:
2011-05-20
期刊:
影响因子:
3.5
通讯作者:
Buijs RM
Buijs RM
中科院分区:
生物学3区
文献类型:
--
作者:
Kalsbeek A;Scheer FA;Perreau-Lenz S;La Fleur SE;Yi CX;Fliers E;Buijs RM

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在这篇综述中,我们首先介绍了SCN用来加强其在身体上的节律性的解剖学途径,特别是其能量平衡系统。实验数据显示,通过在活动期开始时激活食欲素系统,生物钟不仅确保我们按时醒来,而且我们的葡萄糖代谢和心血管系统也为活动增加做好了准备。然而,当我们的日常生活与环境不完全同步时,这种高度集成系统的缺点就会显现出来。因此,除了增加体力活动和减少高能量食物的摄入量外,一个光线充足、充分共振的生物钟也可能有助于抵御当今全天候社会日益增加的“糖尿病”压力。
In this review we first present the anatomical pathways used by the SCN to enforce its rhythmicity onto the body, especially its energy homeostatic system. The experimental data show that by activating the orexin system at the start of the active phase, the biological clock not only ensures that we wake up on time, but also that our glucose metabolism and cardiovascular system are prepared for increased activity. The drawback of such a highly integrated system, however, becomes visible when our daily lives are not fully synchronized with the environment. Thus, in addition to increased physical activity and decreased intake of high-energy food, also a well-lighted and fully resonating biological clock may help to withstand the increasing “diabetogenic” pressure of today’s 24/7 society.
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