Circadian disruption and SCN control of energy metabolism.
Circadian disruption and SCN control of energy metabolism.
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DOI:
10.1016/j.febslet.2011.03.021
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发表时间:
2011-05-20
期刊:
影响因子:
3.5
通讯作者:
Buijs RM
中科院分区:
文献类型:
--
作者:
Kalsbeek A;Scheer FA;Perreau-Lenz S;La Fleur SE;Yi CX;Fliers E;Buijs RM
In this review we first present the anatomical pathways used by the SCN to enforce its rhythmicity onto the body, especially its energy homeostatic system. The experimental data show that by activating the orexin system at the start of the active phase, the biological clock not only ensures that we wake up on time, but also that our glucose metabolism and cardiovascular system are prepared for increased activity. The drawback of such a highly integrated system, however, becomes visible when our daily lives are not fully synchronized with the environment. Thus, in addition to increased physical activity and decreased intake of high-energy food, also a well-lighted and fully resonating biological clock may help to withstand the increasing “diabetogenic” pressure of today’s 24/7 society.
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