Oscillations and hippocampal-prefrontal synchrony.

Oscillations and hippocampal-prefrontal synchrony.
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DOI:
10.1016/j.conb.2011.02.012
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发表时间:
2011-06
影响因子:
5.7
通讯作者:
Gordon JA
Gordon JA
中科院分区:
医学2区
文献类型:
--
作者:
Gordon JA

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海马体是许多类型记忆所需的结构,它连接到内侧前额叶皮层,这是一个在有意行为期间帮助引导神经元信息流的区域。越来越多的证据表明,振荡调节这两个区域之间的通信。Theta节律可能有助于记忆任务期间海马向内侧前额叶皮层的输入,也可能整合内侧前额叶皮层中一系列功能相关的γ介导的细胞组装。在慢波睡眠期间,海马尖波波纹和内侧前额叶皮层纺锤波的时间协调可能是记忆变得不依赖于海马的过程的重要组成部分。使用啮齿动物模型的研究表明,振荡锁相在精神分裂症中受到干扰,强调了需要更多的研究振荡同步在大脑前额叶-前额叶网络。
The hippocampus, a structure required for many types of memory, connects to the medial prefrontal cortex, an area that helps direct neuronal information streams during intentional behaviors. Increasing evidence suggests that oscillations regulate communication between these two regions. Theta rhythms may facilitate hippocampal inputs to the medial prefrontal cortex during mnemonic tasks and may also integrate series of functionally relevant gamma-mediated cell assemblies in the medial prefrontal cortex. During slow-wave sleep, temporal coordination of hippocampal sharp wave-ripples and medial prefrontal cortex spindles may be an important component of the process by which memories become hippocampus-independent. Studies using rodent models indicate that oscillatory phase-locking is disturbed in schizophrenia, emphasizing the need for more studies of oscillatory synchrony in the hippocampal–prefrontal network.
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