Colonization of a commercial broiler line by Campylobacter is under limited genetic control and does not significantly impair performance or intestinal health.
Colonization of a commercial broiler line by Campylobacter is under limited genetic control and does not significantly impair performance or intestinal health.
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DOI：
10.3382/ps/pey295
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发表时间：
2018-12-01
期刊：
影响因子：
4.4
通讯作者：
Avendano S
中科院分区：
文献类型：
--
作者：
Bailey RA;Kranis A;Psifidi A;Watson KA;Rothwell L;Hocking PM;Kaiser P;Stevens MP;Avendano S
弯曲杆菌是人类食源性腹泻病的主要细菌原因，来源归因研究明确指出，处理或食用禽肉是一个关键的风险因素。弯曲杆菌在禽类肠道中大量定植，并在鸡群中迅速传播。因此，需要设计减少家禽群中弯曲杆菌种群的策略。已经有大量的研究旨在了解弯曲杆菌在家禽中的流行病学和传播特征，作为降低家禽携带率和减少人类感染的手段。一种潜在的控制策略是对家禽进行遗传选择，以提高对弯曲杆菌定殖的抗性。在用弯曲杆菌进行实验性挑战后的近交群体中已经证明了定植的遗传控制潜力，其中已经鉴定了与抗性相关的数量性状基因座。目前，在文献中没有弯曲杆菌在商业肉鸡品系中定殖的遗传基础的信息，并且不知道这些QTL是否在商业肉鸡品系中发现。本研究的目的是估计与弯曲杆菌负荷和肠道健康和生产性状的遗传相关性的遗传参数，肉鸡自然暴露于弯曲杆菌。分析结果表明，弯曲杆菌负荷的遗传力估计值较低但显著（0.095 ± 0.037），这表明遗传基础有限，非遗传因素对肉鸡中发现的弯曲杆菌水平有较大影响。此外，通过检查宏观肠道健康和吸收能力，我们的研究表明，弯曲杆菌在所研究的肉鸡品系中自然暴露后对肠道健康和禽类生长没有不利影响。这些数据表明，虽然有一个遗传成分，弯曲杆菌定植值得进一步调查，有很大比例的表型变异的影响下，非遗传效应。因此，弯曲杆菌的控制将需要理解和操纵非遗传宿主和环境因素。
Campylobacter is the leading bacterial cause of foodborne diarrheal illness in humans and source attribution studies unequivocally identify handling or consumption of poultry meat as a key risk factor. Campylobacter colonizes the avian intestines in high numbers and rapidly spreads within flocks. A need therefore exists to devise strategies to reduce Campylobacter populations in poultry flocks. There has been a great deal of research aiming to understand the epidemiology and transmission characteristics of Campylobacter in poultry as a means to reduce carriage rates in poultry and reduce infection in humans. One potential strategy for control is the genetic selection of poultry for increased resistance to colonization by Campylobacter. The potential for genetic control of colonization has been demonstrated in inbred populations following experimental challenge with Campylobacter where quantitative trait loci associated with resistance have been identified. Currently in the literature there is no information of the genetic basis of Campylobacter colonization in commercial broiler lines and it is unknown whether these QTL are found in commercial broiler lines. The aim of this study was to estimate genetic parameters associated with Campylobacter load and genetic correlations with gut health and production traits following natural exposure of broiler chickens to Campylobacter. The results from the analysis show a low but significant heritability estimate (0.095 ± 0.037) for Campylobacter load which indicates a limited genetic basis and that non-genetic factors have a greater influence on the level of Campylobacter found in the broiler chicken. Furthermore, through examination of macroscopic intestinal health and absorptive capacity, our study indicated that Campylobacter has no detrimental effects on intestinal health and bird growth following natural exposure in the broiler line under study. These data indicate that whilst there is a genetic component to Campylobacter colonization worthy of further investigation, there is a large proportion of phenotypic variance under the influence of non-genetic effects. As such the control of Campylobacter will require understanding and manipulation of non-genetic host and environmental factors.
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影响因子：
15.8
作者：
Havelaar AH;Kirk MD;Torgerson PR;Gibb HJ;Hald T;Lake RJ;Praet N;Bellinger DC;de Silva NR;Gargouri N;Speybroeck N;Cawthorne A;Mathers C;Stein C;Angulo FJ;Devleesschauwer B;World Health Organization Foodborne Disease Burden Epidemiology Reference Group
通讯作者：
World Health Organization Foodborne Disease Burden Epidemiology Reference Group
影响因子：
3.7
作者：
Bishop SC;Woolliams JA
通讯作者：
Woolliams JA
DOI：
10.1534/g3.113.006031
发表时间：
2013-05-20
期刊：
G3 (Bethesda, Md.)
影响因子：
--
作者：
Connell S;Meade KG;Allan B;Lloyd AT;Downing T;O'Farrelly C;Bradley DG
通讯作者：
Bradley DG
影响因子：
1.4
作者：
Dhillon, AS;Shivaprasad, HL;Bandli, D
通讯作者：
Bandli, D
影响因子：
4.4
作者：
Gormley, Fraser J.;Bailey, Richard A.;Koerhuis, Alfons N. M.
通讯作者：
Koerhuis, Alfons N. M.