Associations of audiometric hearing and speech-in-noise performance with cognitive decline among older adults: The Baltimore Longitudinal Study of Aging (BLSA).
Associations of audiometric hearing and speech-in-noise performance with cognitive decline among older adults: The Baltimore Longitudinal Study of Aging (BLSA).
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DOI：
10.3389/fneur.2022.1029851
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发表时间：
2022
影响因子：
3.4
通讯作者：
中科院分区：
文献类型：
--
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听力损失和认知能力下降之间的联系主要是通过纯音测听来确定的，纯音测听反映了周围听力能力。噪声环境下的言语表现反映中枢听力能力，在以往的文献中较为局限。我们研究了听力测量和噪音中言语表现与认知能力下降的纵向关联。我们在2012-2019年巴尔的摩老龄化纵向研究中研究了702名年龄≥60岁的参与者。采用认知评估电池对受试者的整体和特定领域（语言、记忆、注意、执行功能、视觉空间能力）的认知表现进行评估。将纯音测听得到的0.5、1、2和4千赫兹的听力阈值进行平均，以计算好耳纯音平均值（PTA），并将参与者分为听力损失（bbb25分贝听力水平[dB HL]）和正常听力（≤25分贝HL）。语音噪音测试通过快速语音噪音测试（QuickSIN）来评估，参与者被分为低于中位数（较差）或高于中位数的表现。使用随机截距和斜率的线性混合效应模型来评估基线认知表现和听力状况引起的认知衰退。模型根据人口统计、生活方式和疾病因素进行调整。听力损失的参与者表现出相似的基线认知能力，但整体认知功能、语言、执行功能和注意力下降更快。QuickSIN得分低于中位数的参与者在所有领域的基线认知表现都较差，在整体认知功能、语言、记忆、执行功能和注意力方面下降更快。听力测量可能是延缓认知能力下降的目标。噪音中的语音表现可能是一种新的标记，可能对记忆衰退更敏感。
Established associations between hearing loss and cognitive decline were primarily defined by pure-tone audiometry, which reflects peripheral hearing ability. Speech-in-noise performance, which reflects central hearing ability, is more limited in prior literature. We examined the longitudinal associations of audiometric hearing and speech-in-noise performance with cognitive decline. We studied 702 participants aged ≥60 years in the Baltimore Longitudinal Study of Aging 2012–2019. Global and domain-specific (language, memory, attention, executive function, visuospatial ability) cognitive performance were assessed by the cognitive assessment battery. Hearing thresholds at 0.5, 1, 2, and 4 kilohertz obtained from pure-tone audiometry were averaged to calculate better-ear pure-tone average (PTA) and participants were categorized as having hearing loss (>25 decibels hearing level [dB HL]) or normal hearing (≤25 dB HL). Speech-in-noise performance was assessed by the Quick Speech-in-Noise (QuickSIN) test, and participants were categorized as having below-median (worse) or above-median performance. Linear mixed effects models with random intercepts and slopes were used to assess baseline cognitive performance and cognitive decline by hearing status. Models adjusted for demographic, lifestyle and disease factors. Participants with audiometric hearing loss showed similar baseline cognitive performance but faster decline in global cognitive function, language, executive function, and attention. Participants with below-median QuickSIN score showed worse baseline cognitive performance in all domains and faster decline in global cognitive function, language, memory, executive function and attention. Audiometric hearing might be targeted to delay cognitive decline. Speech-in-noise performance might be a novel marker and might be more sensitive to memory decline.
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DOI：
10.1093/gerona/glr115
发表时间：
2011-10-01
影响因子：
5.1
作者：
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通讯作者：
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影响因子：
2.4
作者：
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影响因子：
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10.1093/gerona/glz189
发表时间：
2020-03-01
影响因子：
5.1
作者：
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通讯作者：
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影响因子：
5.4
作者：
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