Differential Age-Related Changes in Structural Covariance Networks of Human Anterior and Posterior Hippocampus.
Differential Age-Related Changes in Structural Covariance Networks of Human Anterior and Posterior Hippocampus.
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人类前海马和后海马结构协方差网络与年龄相关的差异变化
DOI：
10.3389/fphys.2018.00518
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发表时间：
2018
影响因子：
4
通讯作者：
Li S
中科院分区：
文献类型：
--
作者：
Li X;Li Q;Wang X;Li D;Li S
海马在记忆功能中起着重要的作用，依赖于分布的脑区之间的信息交互。海马沿其长轴沿着可分为结构和功能不同的前、后两部分。本研究旨在探讨正常老化对前海马（aHPC）和后海马（pHPC）结构协方差的影响。在这项研究中，选择了240名年龄在18 - 89岁之间的健康受试者，并将其细分为年轻组（18 - 23岁）、中年组（30 - 58岁）和老年组（61 - 89岁）。根据钩突尖在MNI间隙中的位置将aHPC和pHPC分为两类。然后，结构协方差网络的构建，通过检查其与其他大脑区域的灰质体积的协方差。最后，年龄对这些海马切片的结构协方差的影响进行了探讨。我们发现aHPC和pHPC具有不同的结构协方差模式，但它们都与内侧颞叶和颞叶相关。此外，发现aHPC的协方差增加和减少，但仅发现pHPC的协方差随年龄增加（p <0.05，家族误差校正）。这些减少的连接发生在默认模式网络中，而增加的连接主要发生在与海马体不同的其他记忆系统中。本研究揭示了不同年龄对aHPC和pHPC结构网络的影响，为了解海马在正常衰老中的机制提供了必要的信息。
The hippocampus plays an important role in memory function relying on information interaction between distributed brain areas. The hippocampus can be divided into the anterior and posterior sections with different structure and function along its long axis. The aim of this study is to investigate the effects of normal aging on the structural covariance of the anterior hippocampus (aHPC) and the posterior hippocampus (pHPC). In this study, 240 healthy subjects aged 18–89 years were selected and subdivided into young (18–23 years), middle-aged (30–58 years), and older (61–89 years) groups. The aHPC and pHPC was divided based on the location of uncal apex in the MNI space. Then, the structural covariance networks were constructed by examining their covariance in gray matter volumes with other brain regions. Finally, the influence of age on the structural covariance of these hippocampal sections was explored. We found that the aHPC and pHPC had different structural covariance patterns, but both of them were associated with the medial temporal lobe and insula. Moreover, both increased and decreased covariances were found with the aHPC but only increased covariance was found with the pHPC with age (p < 0.05, family-wise error corrected). These decreased connections occurred within the default mode network, while the increased connectivity mainly occurred in other memory systems that differ from the hippocampus. This study reveals different age-related influence on the structural networks of the aHPC and pHPC, providing an essential insight into the mechanisms of the hippocampus in normal aging.
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DOI：
10.1162/netn_a_00016
发表时间：
2017-10-01
期刊：
Network neuroscience (Cambridge, Mass.)
影响因子：
--
作者：
DuPre E;Spreng RN
通讯作者：
Spreng RN
影响因子：
34.7
作者：
Alexander-Bloch, Aaron;Giedd, Jay N.;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
5.2
作者：
Andrews-Hanna JR;Smallwood J;Spreng RN
通讯作者：
Spreng RN
影响因子：
2.5
作者：
Chen, Karren H. M.;Chuah, Lisa Y. M.;Chee, Michael W. L.
通讯作者：
Chee, Michael W. L.