Essential Roles of Efferent Duct Multicilia in Male Fertility.
Essential Roles of Efferent Duct Multicilia in Male Fertility.
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DOI：
10.3390/cells11030341
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发表时间：
2022-01-20
期刊：
影响因子：
6
通讯作者：
Takemaru KI
中科院分区：
文献类型：
--
作者：
Hoque M;Kim EN;Chen D;Li FQ;Takemaru KI
纤毛是细胞表面的毛状细胞器。纤毛参与了从机械感觉到流体运动的各种生物过程。睫状体功能障碍导致了大量的人类疾病，称为纤毛病。虽然不运动的初级纤毛是普遍存在的，但运动的多纤毛仅见于身体的有限部位，如呼吸道、输卵管、输出管和脑室。多纤毛以鞭子样的运动跳动，在上皮的顶端表面上产生流体流动。一致的纤毛运动提供了清除气道粘液和碎片、将卵子从卵巢运输到子宫、维持精子悬浮以及使脑中的脑脊液循环的关键驱动力。在男性生殖道中，多纤毛细胞（MCCs）在19世纪中期首次被描述，但直到最近它们在男性生育中的重要性仍然难以捉摸。MCC存在于输出管中，输出管是连接睾丸和附睾的小的、高度卷曲的小管，并且在男性生育中起重要作用。在这篇综述中，我们将介绍多纤毛发生，讨论多纤毛缺陷男性不育的小鼠模型，并总结我们目前对多纤毛在男性生殖道中的生物学功能的认识。
Cilia are microtubule-based hair-like organelles on the cell surface. Cilia have been implicated in various biological processes ranging from mechanosensation to fluid movement. Ciliary dysfunction leads to a plethora of human diseases, known as ciliopathies. Although non-motile primary cilia are ubiquitous, motile multicilia are found in restricted locations of the body, such as the respiratory tract, the oviduct, the efferent duct, and the brain ventricles. Multicilia beat in a whip-like motion to generate fluid flow over the apical surface of an epithelium. The concerted ciliary motion provides the driving force critical for clearing airway mucus and debris, transporting ova from the ovary to the uterus, maintaining sperm in suspension, and circulating cerebrospinal fluid in the brain. In the male reproductive tract, multiciliated cells (MCCs) were first described in the mid-1800s, but their importance in male fertility remained elusive until recently. MCCs exist in the efferent ducts, which are small, highly convoluted tubules that connect the testis to the epididymis and play an essential role in male fertility. In this review, we will introduce multiciliogenesis, discuss mouse models of male infertility with defective multicilia, and summarize our current knowledge on the biological function of multicilia in the male reproductive tract.
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影响因子：
21.3
作者：
通讯作者：
--
DOI：
10.1042/bcj20200277
发表时间：
2020-09-30
期刊：
The Biochemical journal
影响因子：
--
作者：
Conduit SE;Vanhaesebroeck B
通讯作者：
Vanhaesebroeck B
影响因子：
64.5
作者：
Chaki M;Airik R;Ghosh AK;Giles RH;Chen R;Slaats GG;Wang H;Hurd TW;Zhou W;Cluckey A;Gee HY;Ramaswami G;Hong CJ;Hamilton BA;Cervenka I;Ganji RS;Bryja V;Arts HH;van Reeuwijk J;Oud MM;Letteboer SJ;Roepman R;Husson H;Ibraghimov-Beskrovnaya O;Yasunaga T;Walz G;Eley L;Sayer JA;Schermer B;Liebau MC;Benzing T;Le Corre S;Drummond I;Janssen S;Allen SJ;Natarajan S;O'Toole JF;Attanasio M;Saunier S;Antignac C;Koenekoop RK;Ren H;Lopez I;Nayir A;Stoetzel C;Dollfus H;Massoudi R;Gleeson JG;Andreoli SP;Doherty DG;Lindstrad A;Golzio C;Katsanis N;Pape L;Abboud EB;Al-Rajhi AA;Lewis RA;Omran H;Lee EY;Wang S;Sekiguchi JM;Saunders R;Johnson CA;Garner E;Vanselow K;Andersen JS;Shlomai J;Nurnberg G;Nurnberg P;Levy S;Smogorzewska A;Otto EA;Hildebrandt F
通讯作者：
Hildebrandt F
影响因子：
64.8
作者：
Al Jord, Adel;Lemaitre, Anne-Iris;Meunier, Alice
通讯作者：
Meunier, Alice
影响因子：
4
作者：
Aprea I;Nöthe-Menchen T;Dougherty GW;Raidt J;Loges NT;Kaiser T;Wallmeier J;Olbrich H;Strünker T;Kliesch S;Pennekamp P;Omran H
通讯作者：
Omran H