Distinct activation of the sympathetic adreno-medullar system and hypothalamus pituitary adrenal axis following the caloric vestibular test in healthy subjects.
Distinct activation of the sympathetic adreno-medullar system and hypothalamus pituitary adrenal axis following the caloric vestibular test in healthy subjects.
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DOI：
10.1371/journal.pone.0193963
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Dima-Cozma LC
中科院分区：
文献类型：
--
作者：
Cozma S;Ghiciuc CM;Damian L;Pasquali V;Saponaro A;Lupusoru EC;Patacchioli FR;Dima-Cozma LC
前庭急性应激诱导可逆性警觉性反应，涉及交感肾上腺-髓质系统和下丘脑-垂体-肾上腺轴反应。本研究旨在评估健康受试者急性应激诱导的唾液α-淀粉酶和唾液皮质醇生成与心血管反应性的关系。研究了48名年轻健康男性志愿者在基础条件下和在空气热量前庭测试达到最大眼球震颤反应后的不同时间进行了检查。记录心率、收缩压、舒张压和平均动脉压，同时测定唾液α-淀粉酶和唾液皮质醇。在热量前庭测试结束时，使用感知压力量表问卷来测量任务引起的自我感知压力影响，并将个体得分与入组当天的得分进行比较。热前庭测试诱发眩晕后，唾液α-淀粉酶和皮质醇在急性应激后的生成有明显的变化趋势，采用学生t检验比较α-淀粉酶和皮质醇各自插值回归线的斜率，差异有统计学意义（t = -3.283, p<0.001）；唾液皮质醇生成的增加与唾液α-淀粉酶浓度的降低相对应。此外，唾液生物标志物的改变与心率、收缩压和平均动脉压的持续变化有关。本研究使用空气热量前庭测试任务作为应激源，证明了前庭刺激的急性激素应激反应与心血管输出之间的联系。然而，在我们能够确定前庭刺激引起的一致心血管活动变化的潜在重要性以及对人类心血管调节和直立耐受的可能功能后果之前，还需要进一步的研究。
The vestibular acute stress induces reversible alert-like reactions that involve the sympathetic adrenal-medullar system and hypothalamic-pituitary-adrenal axis responses. The present study aimed to evaluate salivary α-amylase and salivary cortisol production in relation with cardiovascular reactivity induced by acute stress in healthy subjects. Forty-eight young healthy male volunteers were examined under basal conditions and at various times after reaching the maximal nystagmic reaction following air caloric vestibular test. Heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded at the same time as measurement of the salivary α-amylase and salivary cortisol. At the end of the caloric vestibular test session, perceived stress scale questionnaires were administered to measure the self-perceived stress impact induced by the task, and individual scores were compared with those measured on the enrollment day. Following caloric vestibular test-evoked vertigo, salivary α-amylase and cortisol showed distinct trends in their production after acute stress: Student’s t-test was used to compare the α-amylase vs cortisol slopes of the respective interpolated regression lines, and the difference was significant (t = -3.283; p<0.001); an increase in salivary cortisol production corresponded with a decrease in the salivary α-amylase concentration. In addition, salivary biomarker modifications were associated with consistent changes in the heart rate, systolic blood pressure and mean arterial pressure. Using the air caloric vestibular test task as a stressor, the present study demonstrated a connection between the acute hormonal stress response to vestibular stimulation and cardiovascular output. However, further research is needed before we can define the potential importance of the consistent cardiovascular activity changes evoked by vestibular stimulation and the possible functional consequences for cardiovascular regulation and orthostatic tolerance in humans.
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影响因子：
168.9
作者：
Hall, Kevin D.;Sacks, Gary;Chandramohan, Dhruva;Chow, Carson C.;Wang, Y. Claire;Gortmaker, Steven L.;Swinburn, Boyd A.
通讯作者：
Swinburn, Boyd A.
影响因子：
2.4
作者：
Ahn RS;Lee YJ;Choi JY;Kwon HB;Chun SI
通讯作者：
Chun SI
影响因子：
3.4
作者：
Hammam E;Macefield VG
通讯作者：
Macefield VG
影响因子：
5.8
作者：
COSTA, F;LAVIN, P;BIAGGIONI, I
通讯作者：
BIAGGIONI, I
DOI：
10.1111/j.1475-097x.1996.tb00731.x
发表时间：
1996-07-01
期刊：
CLINICAL PHYSIOLOGY
影响因子：
--
作者：
Chatterton, RT;Vogelsong, KM;Hudgens, GA
通讯作者：
Hudgens, GA