Increased alpha 1-adrenergic vascular sensitivity during development of hypertension in conscious dogs.
Increased alpha 1-adrenergic vascular sensitivity during development of hypertension in conscious dogs.
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在意识清醒的狗患高血压期间，α1-肾上腺素能血管敏感性增加。
DOI：
10.1152/ajpheart.1993.264.4.h1259
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Vatner,SF
中科院分区：
文献类型：
--
作者：
Uemura,N;Vatner,DE;Shen,YT;Wang,J;Vatner,SF
这项研究的目的是确定肾周高血压发展过程中血管反应性增强是选择性的还是非特异性的。本文观察了去甲肾上腺素(NE)、去甲肾上腺素(PE)、血管紧张素II(Ang II)和加压素(VP)对清醒犬平均动脉压、总外周阻力(TPR)和主动脉压-内径关系的影响。NE升高高血压患者的TPR显著高于正常血压(P<；0.01)，而血管紧张素转换酶II和VP在高血压前后的升高相似。对主动脉压力-直径关系的分析也表明，在高血压的发展过程中，对NE和PE的反应有显著的变化(P<；0.05)，但对Ang II和VP的反应不明显。在正常血压的狗中，小剂量的血管紧张素-II不仅增强了对NE和PE的收缩反应，也增强了对VP的收缩反应。与高血压不同的是，在神经节阻断后注射血管紧张素转换酶II的情况下，不再观察到对PE和NE的增强反应。用[~3H]哌唑嗪结合法测定，高血压犬主动脉组织膜上α1-肾上腺素能受体密度高于对照组(P<0.05)。因此，在发生肾周高血压期间，主动脉和阻力血管对α1-肾上腺素能刺激的血管反应性增强，但不是对所有血管收缩药。其机制似乎与α1-肾上腺素能受体密度增加有关。
The goal of this study was to determine whether enhanced vascular responsiveness during the development of perinephritic hypertension is selective or nonspecific. The effects of graded infusions of norepinephrine (NE), phenylephrine (PE), angiotensin II (ANG II), and vasopressin (VP) were examined on mean arterial pressure, total peripheral resistance (TPR), and aortic pressure-diameter relationships in conscious dogs. NE increased TPR significantly greater (P < 0.01) in hypertension than normotension, as did PE infusion, whereas ANG II and VP increased TPR similarly before and after hypertension. Analysis of aortic pressure-diameter relationships also demonstrated significant (P < 0.05) shifts in response to NE and PE, but not ANG II and VP, during the development of hypertension. In normotensive dogs, low doses of ANG II infusion also enhanced the vasoconstrictor response not only to NE and PE but also to VP. In contrast to what was observed in hypertension, in the presence of ANG II infusion after ganglionic blockade, enhanced responses to PE and NE were no longer observed. The alpha 1-adrenergic receptor density in membrane preparations from aortic tissue, as determined by [3H]prazosin binding, was higher (P < 0.05) in hypertensive dogs than control dogs. Thus the vascular responsiveness in the aorta and resistance vessels is enhanced to alpha 1-adrenergic stimulation, but not to all vasoconstrictors, during developing perinephritic hypertension. The mechanism appears to involve increased alpha 1-adrenergic receptor density.
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DOI：
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