Rheumatoid arthritis T cell and muscle oxidative metabolism associate with exercise-induced changes in cardiorespiratory fitness.
Rheumatoid arthritis T cell and muscle oxidative metabolism associate with exercise-induced changes in cardiorespiratory fitness.
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DOI：
10.1038/s41598-022-11458-4
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发表时间：
2022-05-06
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
风湿性关节炎（RA）T细胞通过代谢重编程驱动自身免疫功能，减少氧化代谢。运动训练改善心肺健康（即，全身性氧化代谢），因此可能影响RA T细胞氧化代谢功能。在RA参与者的这项试点研究中，我们利用高强度间歇训练（HIIT）运动计划的异质性反应，以确定心肺功能改善与外周T细胞和骨骼肌氧化代谢变化之间的关系。在12个先前久坐的人与血清阳性RA，最大心肺运动试验，空腹血液，股外侧肌活检前和后10周的HIIT。HIIT后，RA心肺功能的改善与RA CD4 + T细胞基础和最大呼吸以及骨骼肌肉毒碱乙酰转移酶（CrAT）酶活性的变化相关。此外，CD4 + T细胞呼吸的变化与初始CD4 + CCR7 + CD45RA + T细胞、肌肉CrAT和肌肉中链酰基肉毒碱和脂肪氧化基因表达谱的变化相关。总之，运动训练期间心肺适能和骨骼肌氧化代谢分子标志物的调节会导致T细胞代谢的变化。因此，改善RA心肺适应性的运动训练可能对管理病理相关的免疫和肌肉功能障碍有价值。试验注册：ClinicalTrials.gov，NCT 02528344。于2015年8月19日注册。
Rheumatoid arthritis (RA) T cells drive autoimmune features via metabolic reprogramming that reduces oxidative metabolism. Exercise training improves cardiorespiratory fitness (i.e., systemic oxidative metabolism) and thus may impact RA T cell oxidative metabolic function. In this pilot study of RA participants, we took advantage of heterogeneous responses to a high-intensity interval training (HIIT) exercise program to identify relationships between improvements in cardiorespiratory fitness with changes in peripheral T cell and skeletal muscle oxidative metabolism. In 12 previously sedentary persons with seropositive RA, maximal cardiopulmonary exercise tests, fasting blood, and vastus lateralis biopsies were obtained before and after 10 weeks of HIIT. Following HIIT, improvements in RA cardiorespiratory fitness were associated with changes in RA CD4 + T cell basal and maximal respiration and skeletal muscle carnitine acetyltransferase (CrAT) enzyme activity. Further, changes in CD4 + T cell respiration were associated with changes in naïve CD4 + CCR7 + CD45RA + T cells, muscle CrAT, and muscle medium-chain acylcarnitines and fat oxidation gene expression profiles. In summary, modulation of cardiorespiratory fitness and molecular markers of skeletal muscle oxidative metabolism during exercise training paralleled changes in T cell metabolism. Exercise training that improves RA cardiorespiratory fitness may therefore be valuable in managing pathologically related immune and muscle dysfunction. Trial registration: ClinicalTrials.gov, NCT02528344. Registered on 19 August 2015.
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影响因子：
13.3
作者：
Liu, Xinyi;Tedeschi, Sara K.;Sparks, Jeffrey A.
通讯作者：
Sparks, Jeffrey A.
影响因子：
4.4
作者：
Liu D;Wang R;Grant AR;Zhang J;Gordon PM;Wei Y;Chen P
通讯作者：
Chen P
DOI：
10.1002/art.23719
发表时间：
2008-06-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Giles, Jon T.;Ling, Shari M.;Bathon, Joan M.
通讯作者：
Bathon, Joan M.
影响因子：
2.1
作者：
Huffman, K. M.;Pieper, C. F.;Kraus, W. E.
通讯作者：
Kraus, W. E.
影响因子：
4.1
作者：
Dorneles, Gilson P.;da Silva, Igor;Romao, Pedro R. T.
通讯作者：
Romao, Pedro R. T.