Carbonate apatite artificial bone.
Carbonate apatite artificial bone.
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DOI：
10.1080/14686996.2021.1947120
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发表时间：
2021
影响因子：
5.5
通讯作者：
Hayashi K
中科院分区：
文献类型：
--
作者：
Ishikawa K;Hayashi K
骨磷灰石不是羟基磷灰石（HAp），而是碳酸磷灰石（CO 3Ap），其在磷灰石结构中包含6-9质量%的碳酸盐。CO 3Ap块不能通过烧结制造，因为其在烧结温度下热分解。化学纯（100%）CO 3Ap人工骨最近通过在水溶液中使用前体（例如碳酸钙块）的溶解-沉淀反应来制造。本文对CO 3 Ap人工骨的制备方法及其临床和动物实验结果进行了沿着。CO 3Ap人工骨可被破骨细胞吸收，并促进成骨细胞的分化。因此，CO 3Ap表现出比HAp高得多的骨传导性，并通过骨重建被新骨取代。颗粒型CO 3Ap人工骨于2017年在日本获批临床使用。以CaCO 3蜂窝块为前驱体，采用挤出机制备了蜂窝型CO 3Ap人工骨。蜂窝状CO 3Ap人工骨允许垂直骨增量。还使用CaCO 3涂覆的钛板作为前体制造了CO 3Ap涂覆的钛板。粘接强度高达76.8 MPa，具有良好的组织反应性和高骨传导性。
Bone apatite is not hydroxyapatite (HAp), it is carbonate apatite (CO3Ap), which contains 6–9 mass% carbonate in an apatitic structure. The CO3Ap block cannot be fabricated by sintering because of its thermal decomposition at the sintering temperature. Chemically pure (100%) CO3Ap artificial bone was recently fabricated through a dissolution–precipitation reaction in an aqueous solution using a precursor, such as a calcium carbonate block. In this paper, methods of fabricating CO3Ap artificial bone are reviewed along with their clinical and animal results. CO3Ap artificial bone is resorbed by osteoclasts and upregulates the differentiation of osteoblasts. As a result, CO3Ap demonstrates much higher osteoconductivity than HAp and is replaced by new bone via bone remodeling. Granular-type CO3Ap artificial bone was approved for clinical use in Japan in 2017. Honeycomb-type CO3Ap artificial bone is fabricated using an extruder and a CaCO3 honeycomb block as a precursor. Honeycomb CO3Ap artificial bone allows vertical bone augmentation. A CO3Ap-coated titanium plate has also been fabricated using a CaCO3-coated titanium plate as a precursor. The adhesive strength is as high as 76.8 MPa, with excellent tissue response and high osteoconductivity.
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影响因子：
4.3
作者：
Cochran, DL;Buser, D;Simpson, JP
通讯作者：
Simpson, JP
影响因子：
2.5
作者：
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通讯作者：
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影响因子：
4.9
作者：
Karashima, Satoshi;Takeuchi, Akari;Ishikawa, Kunio
通讯作者：
Ishikawa, Kunio
影响因子：
3.4
作者：
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通讯作者：
Ishikawa K
影响因子：
5.2
作者：
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通讯作者：
Ishikawa, Kunio