Inflammatory cytokines in general and central obesity and modulating effects of physical activity.
Inflammatory cytokines in general and central obesity and modulating effects of physical activity.
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DOI：
10.1371/journal.pone.0121971
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Himmerich H
中科院分区：
文献类型：
--
作者：
Schmidt FM;Weschenfelder J;Sander C;Minkwitz J;Thormann J;Chittka T;Mergl R;Kirkby KC;Faßhauer M;Stumvoll M;Holdt LM;Teupser D;Hegerl U;Himmerich H
肥胖症的慢性全身性炎症源于内脏脂肪组织的局部免疫反应。然而，评估范围广泛的炎症介导的细胞因子及其与体力活动和脂肪测量的关系几乎没有报道。在全身性肥胖、向心性肥胖和非肥胖受试者中，描述多种促炎和抗炎细胞因子的特征以及体力活动和能量消耗的影响。一项包括117名肥胖患者（体重指数（BMI）≥ 30）和83名非肥胖社区志愿者的横断面研究。检测血清白细胞介素（IL）-2、IL-4、IL-5、IL-10、IL-12、IL-13、粒细胞-巨噬细胞集落刺激因子（GM-CSF）、干扰素（IFN）-γ和肿瘤坏死因子（TNF）-α水平。用体动记录仪评估体力活动和能量消耗（MET）。脂肪测量包括BMI、体重、腹围、腰围和臀围、腰臀比（WHR）和腰高比（WHtR）。全身性肥胖与IL-5、IL-10、IL-12、IL-13、IFN-γ和TNF-α水平显著升高相关，中心性肥胖与IL-5、IL-10、IL-12、IL-13和IFN-γ水平显著升高相关。在一般肥胖的参与者中，IL-4，IL-10和IL-13的水平在低体力活动的参与者中显著升高，即使在控制与体力活动呈负相关的BMI时也是如此。细胞因子与脂肪测量显著相关，特别是在肥胖参与者中。结果证实了某些促炎和抗炎细胞因子在肥胖症中的上调。在肥胖受试者中，体力活动可以降低水平，从而减少可能与肥胖、胰岛素抵抗和糖尿病相关的细胞因子的促炎作用。
Chronic systemic inflammation in obesity originates from local immune responses in visceral adipose tissue. However, assessment of a broad range of inflammation-mediating cytokines and their relationship to physical activity and adipometrics has scarcely been reported to date. To characterize the profile of a broad range of pro- and anti-inflammatory cytokines and the impact of physical activity and energy expenditure in individuals with general obesity, central obesity, and non-obese subjects. A cross-sectional study comprising 117 obese patients (body mass index (BMI) ≥ 30) and 83 non-obese community-based volunteers. Serum levels of interleukin (IL)-2, IL-4, IL-5, IL-10, IL-12, IL-13, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon (IFN)-γ and tumor necrosis factor (TNF)-α were measured. Physical activity and energy expenditure (MET) were assessed with actigraphy. Adipometrics comprised BMI, weight, abdominal-, waist- and hip-circumference, waist to hip ratio (WHR), and waist-to-height-ratio (WHtR). General obesity was associated with significantly elevated levels of IL-5, IL-10, IL-12, IL-13, IFN-γ and TNF-α, central obesity with significantly elevated IL-5, IL-10, IL-12, IL-13 and IFN-γ-levels. In participants with general obesity, levels of IL-4, IL-10 and IL-13 were significantly elevated in participants with low physical activity, even when controlled for BMI which was negatively associated with physical acitivity. Cytokines significantly correlated with adipometrics, particularly in obese participants. Results confirm up-regulation of certain pro- and anti-inflammatory cytokines in obesity. In obese subjects, physical activity may lower levels and thus reduce pro-inflammatory effects of cytokines that may link obesity, insulin resistance and diabetes.
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影响因子：
3.7
作者：
Formoso G;Taraborrelli M;Guagnano MT;D'Adamo M;Di Pietro N;Tartaro A;Consoli A
通讯作者：
Consoli A
DOI：
10.1016/j.jaci.2011.03.036
发表时间：
2011-06
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Holguin F;Bleecker ER;Busse WW;Calhoun WJ;Castro M;Erzurum SC;Fitzpatrick AM;Gaston B;Israel E;Jarjour NN;Moore WC;Peters SP;Yonas M;Teague WG;Wenzel SE
通讯作者：
Wenzel SE
肿瘤坏死因子-α的脂肪表达--在与肥胖相关的胰岛素抵抗中的直接作用
影响因子：
56.9
作者：
HOTAMISLIGIL, GS;SHARGILL, NS;SPIEGELMAN, BM
通讯作者：
SPIEGELMAN, BM
DOI：
10.1016/s0140-6736(10)62037-5
发表时间：
2011-02-12
期刊：
Lancet (London, England)
影响因子：
--
作者：
Finucane MM;Stevens GA;Cowan MJ;Danaei G;Lin JK;Paciorek CJ;Singh GM;Gutierrez HR;Lu Y;Bahalim AN;Farzadfar F;Riley LM;Ezzati M;Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index)
通讯作者：
Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index)
DOI：
10.5114/aoms.2012.31614
发表时间：
2012-11-09
期刊：
Archives of medical science : AMS
影响因子：
--
作者：
Ertek S;Cicero A
通讯作者：
Cicero A