Genetic control of alphavirus pathogenesis.
Genetic control of alphavirus pathogenesis.
复制标题
α病毒发病机理的遗传控制。
DOI：
10.1007/s00335-018-9776-1
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Heise MT
中科院分区：
文献类型：
--
作者：
Baxter VK;Heise MT
甲病毒是正义单链RNA病毒科披膜病毒科的成员，随着蚊子媒介扩展到新的地理范围，甲病毒代表了全球重新出现的公共卫生问题。甲病毒属的成员倾向于诱导以皮疹、关节痛和关节炎（基孔肯雅病毒、罗斯河病毒和塞姆利基森林病毒）或脑脊髓炎（东部马脑炎病毒、西部马脑炎病毒和委内瑞拉马脑炎病毒）为特征的临床疾病，尽管一些从最初的急性疾病中恢复的患者可能会发展长期后遗症，无论具体的感染病毒是什么。对人类自然病程和细胞培养及动物模型实验感染的研究表明，宿主遗传学在影响感染易感性和临床疾病严重程度方面发挥着重要作用。全基因组遗传筛选，包括功能缺失筛选、微阵列、RNA测序和候选基因研究，进一步阐明了宿主遗传学在病毒感染应答中的作用，特别是免疫应答被发现主要影响结果。这篇综述描述了宿主遗传因素影响甲病毒发病机制的现有知识，并讨论了新兴技术，这些技术有望提高我们对病毒和宿主遗传学之间复杂相互作用对疾病易感性和临床结果的了解。
Alphaviruses, members of the positive-sense, single-stranded RNA virus family Togaviridae, represent a re-emerging public health concern worldwide as mosquito vectors expand into new geographic ranges. Members of the alphavirus genus tend to induce clinical disease characterized by rash, arthralgia, and arthritis (chikungunya virus, Ross River virus, and Semliki Forest virus) or encephalomyelitis (eastern equine encephalitis virus, western equine encephalitis virus, and Venezuelan equine encephalitis virus), though some patients who recover from the initial acute illness may develop long-term sequelae, regardless of the specific infecting virus. Studies examining the natural disease course in humans and experimental infection in cell culture and animal models reveal that host genetics play a major role in influencing susceptibility to infection and severity of clinical disease. Genome-wide genetic screens, including loss of function screens, microarrays, RNA-sequencing, and candidate gene studies, have further elucidated the role host genetics play in the response to virus infection, with the immune response being found in particular to majorly influence the outcome. This review describes the current knowledge of the mechanisms by which host genetic factors influence alphavirus pathogenesis and discusses emerging technologies that are poised to increase our understanding of the complex interplay between viral and host genetics on disease susceptibility and clinical outcome.
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DOI：
10.4049/jimmunol.1401833
发表时间：
2015-01-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Burrack KS;Montgomery SA;Homann D;Morrison TE
通讯作者：
Morrison TE
影响因子：
5.4
作者：
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通讯作者：
Kehn-Hall K
影响因子：
8.8
作者：
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通讯作者：
Martina, Byron E. E.
影响因子：
2.6
作者：
Aunsmo, Arnfinn;Valle, Paul Steinar;Bruheim, Torkjel
通讯作者：
Bruheim, Torkjel
DOI：
10.1016/j.berh.2011.03.005
发表时间：
2011-06-01
影响因子：
5.2
作者：
Alla, Sanae Ali Ou;Combe, Bernard
通讯作者：
Combe, Bernard