Quantification of Hand Motor Symptoms in Parkinson's Disease: A Proof-of-Principle Study Using Inertial and Force Sensors.
Quantification of Hand Motor Symptoms in Parkinson's Disease: A Proof-of-Principle Study Using Inertial and Force Sensors.
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DOI：
10.1007/s10439-017-1881-x
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发表时间：
2017-10
影响因子：
3.8
通讯作者：
Heida CT
中科院分区：
文献类型：
--
作者：
van den Noort JC;Verhagen R;van Dijk KJ;Veltink PH;Vos MCPM;de Bie RMA;Bour LJ;Heida CT
这项原理验证研究描述了方法，并探索和证明了系统的适用性，现有的微型惯性传感器的手和一个单独的力传感器，客观地量化帕金森病（PD）患者的手部运动症状在临床环境（关闭和药物治疗条件）。四名PD患者在多巴胺能药物治疗的条件下进行了测量。用该系统（称为PowerGlove）测量手指敲击、快速手打开/闭合、手前/后仰、休息时震颤、脑力任务和动力学任务以及手腕僵硬运动。为了证明适用性，提供了在停药与用药条件下测量的患者手部运动症状的各种结局参数。所描述的方法和结果显示了PowerGlove在临床研究环境中的适用性，可使用单个系统客观量化PD患者的手部运动迟缓、震颤和僵硬。PowerGlove测量了患者在所有任务中的停药与服药状态的差异及其大部分结局参数。需要在更大的患者队列中对结局参数的有效性和可靠性进行进一步研究，以获得可帮助临床评价和决策的最佳参数集。
This proof-of-principle study describes the methodology and explores and demonstrates the applicability of a system, existing of miniature inertial sensors on the hand and a separate force sensor, to objectively quantify hand motor symptoms in patients with Parkinson’s disease (PD) in a clinical setting (off- and on-medication condition). Four PD patients were measured in off- and on- dopaminergic medication condition. Finger tapping, rapid hand opening/closing, hand pro/supination, tremor during rest, mental task and kinetic task, and wrist rigidity movements were measured with the system (called the PowerGlove). To demonstrate applicability, various outcome parameters of measured hand motor symptoms of the patients in off- vs. on-medication condition are presented. The methodology described and results presented show applicability of the PowerGlove in a clinical research setting, to objectively quantify hand bradykinesia, tremor and rigidity in PD patients, using a single system. The PowerGlove measured a difference in off- vs. on-medication condition in all tasks in the presented patients with most of its outcome parameters. Further study into the validity and reliability of the outcome parameters is required in a larger cohort of patients, to arrive at an optimal set of parameters that can assist in clinical evaluation and decision-making.
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影响因子：
2.9
作者：
Daneault JF;Carignan B;Codère CÉ;Sadikot AF;Duval C
通讯作者：
Duval C
DOI：
10.3390/s100302129
发表时间：
2010
期刊：
Sensors (Basel, Switzerland)
影响因子：
--
作者：
Gallego JA;Rocon E;Roa JO;Moreno JC;Pons JL
通讯作者：
Pons JL
影响因子：
8.6
作者：
Keijsers, NLW;Horstink, MWIM;Gielen, SCAM
通讯作者：
Gielen, SCAM
影响因子：
4.7
作者：
Powell, Douglas;Threlkeld, A. Joseph;Xia, Ruiping
通讯作者：
Xia, Ruiping
影响因子：
8.6
作者：
Giuffrida, Joseph P.;Riley, David E.;Heldman, Dustin A.
通讯作者：
Heldman, Dustin A.