Bifurcation of the respiratory response to lung inflation in anesthetized dogs.
Bifurcation of the respiratory response to lung inflation in anesthetized dogs.
复制标题
麻醉犬对肺通胀的呼吸反应分叉。
DOI：
10.1016/j.resp.2017.06.010
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发表时间：
2017-10
影响因子：
2.3
通讯作者：
Kowalski KE
中科院分区：
文献类型：
--
作者：
Romaniuk JR;Dick TE;Bruce EN;DiMarco AF;Kowalski KE
许多研究已经证明了肺容量对呼气持续时间（TE）延长的影响，但对新生儿中观察到的TE缩短和呼气终止的理解有限。在14只犬中，评价了呼气期间不同肺充气开始对TE的影响。当在呼气的第一部分（TE的20-60%）应用肺充气时，TE延长。然而，在呼气的第二部分（TE的60-80%），肺充气终止或延长TE;而在呼气的最后一部分（TE的80-90%），肺充气倾向于提前终止呼气。切断双侧迷走神经后，上述效应消失。我们假设TE的延长与Hering-Breuer充气反射有关，该反射增加了被动呼气所需的时间;而缩短TE的能力可能与头部的反常反射有关，该反射用于启动吸气或激活吸气运动活动以制动新生儿中发生的呼气流量。
Numerous studies have demonstrated the effect of lung volume on prolongation of duration of expiration (TE) with limited understanding of the TE shortening and termination of expiration as observed in newborn. In 14 dogs, the effects of varied onset of lung inflation during expiration on the TE were evaluated. When lung inflation was applied in the first part of expiration (20–60% of TE) TE was lengthened. However, in the second portion (60–80% of TE) of expiration, lung inflation either terminated or prolonged TE; whereas in the last portion of expiration (80–90% of TE), lung inflation tended to terminate expiration prematurely. The effects were abolished after bilateral vagotomy. We postulate that prolongation of TE relates to the Hering-Breuer inflation reflex, which increases the time needed for a passive expiration; whereas the ability to shorten TE could relate to Head’s paradoxical reflex acting to initiate inspiration or to activate inspiratory motor activity to brake expiratory flow as occurs in the newborn.
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影响因子：
5.5
作者：
Dutschmann, Mathias;Moerschel, Michael;Dick, Thomas E.
通讯作者：
Dick, Thomas E.
影响因子：
2.3
作者：
Frappell, PB;MacFarlane, PM
通讯作者：
MacFarlane, PM
影响因子：
5.2
作者：
McCallion, N;Lau, R;Morley, CJ
通讯作者：
Morley, CJ
影响因子：
2.7
作者：
MacDonald SM;Tin C;Song G;Poon CS
通讯作者：
Poon CS
影响因子：
3.3
作者：
Arsenault, J;Moreau-Bussière, F;Praud, JP
通讯作者：
Praud, JP