Changes in Affective Behavior and Oxidative Stress after Binge Alcohol in Male and Female Rats.
Changes in Affective Behavior and Oxidative Stress after Binge Alcohol in Male and Female Rats.
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DOI：
10.3390/brainsci11091250
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发表时间：
2021-09-21
期刊：
影响因子：
3.3
通讯作者：
Leasure JL
中科院分区：
文献类型：
--
作者：
Cortez I;Brocardo PS;Leasure JL
酗酒和酒精使用障碍（AUD）是普遍存在的，并与抑郁和焦虑有共病关系。潜在的潜在机制包括酒精暴露引起的神经生理学、遗传学和代谢变化。情绪和焦虑障碍在女性中更常见，但女性是否更容易受到暴食引起的氧化应激以及同时发生的焦虑和抑郁样行为的影响仍然未知。在这里，我们在雄性和雌性大鼠中使用了重复的，每周一次的酗酒范例来研究绝望和焦虑样行为以及大脑氧化应激参数的性别差异。一个单一的酗酒暴露显着升高谷胱甘肽（GSH）水平在前额叶皮层（PFC）的男性和女性的动物。这是伴随着增加脂质过氧化作用的PFC的两种性别。反复（每周一次）暴饮暴食暴露引起的焦虑和抑郁样行为的变化，在男性和女性，并增加谷胱甘肽水平的PFC没有检测到氧化损伤。我们的研究结果表明，反复酗酒暴露的影响影响，无论性别和膜损伤的情况下。
Binge alcohol consumption and alcohol use disorders (AUD) are prevalent, and there is comorbidity with depression and anxiety. Potential underlying mechanisms include neurophysiological, genetic, and metabolic changes resulting from alcohol exposure. Mood and anxiety disorders are more common among women, but whether females are more susceptible to binge-induced oxidative stress and co-occurring anxiety and depression-like behaviors remains unknown. Here, we used a repeated, weekly binge alcohol paradigm in male and female rats to investigate sex differences in despair and anxiety-like behaviors and brain oxidative stress parameters. A single binge alcohol exposure significantly elevated glutathione (GSH) levels in prefrontal cortex (PFC) of both male and female animals. This was accompanied by increased lipid peroxidation in PFC of both sexes. Repeated (once weekly) binge exposure induced changes in anxiety- and depression-like behaviors in both males and females and increased GSH level in the PFC without detectable oxidative damage. Our findings suggest that repeated binge alcohol exposure influences affect regardless of sex and in the absence of membrane damage.
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影响因子：
3.6
作者：
Crews, Fulton Timm;Boettiger, Charlotte Ann
通讯作者：
Boettiger, Charlotte Ann
DOI：
10.7759/cureus.2756
发表时间：
2018-06-07
期刊：
Cureus
影响因子：
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作者：
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通讯作者：
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影响因子：
5.5
作者：
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影响因子：
11.2
作者：
FLOYD, RA;CARNEY, JM
通讯作者：
CARNEY, JM