Gray matter volume correlates of global positive alcohol expectancy in non-dependent adult drinkers.
Gray matter volume correlates of global positive alcohol expectancy in non-dependent adult drinkers.
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DOI：
10.1111/adb.12046
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发表时间：
2014-09
影响因子：
3.4
通讯作者：
Li CS
中科院分区：
文献类型：
--
作者：
Ide JS;Zhang S;Hu S;Matuskey D;Bednarski SR;Erdman E;Farr OM;Li CS
众所周知，酒精的使用和滥用涉及大脑结构的变化。许多成像研究已经检查了依赖性饮酒者的灰质（GM）体积的变化，但关于非依赖性饮酒是否与结构变化有关以及这些变化是否与影响饮酒行为的心理因素（如酒精预期）有关的信息很少。我们使用基于体素的形态测量法（VBM）来研究酒精预期的全球阳性量表（由酒精预期问卷AEQ-3测量）是否与特定的结构标志物相关，以及这些标志物是否与113名成年非依赖性饮酒者（66名女性）的饮酒行为相关。酒精期望值与男女合并的左侧中央前回（PCG）和女性双侧额上上级回（SFG）的GM体积呈正相关，与男性右侧腹侧壳核的GM体积呈负相关。此外，中介分析显示，PCG的GM量介导了酒精预期与过去一年每次平均饮酒次数和每月总饮酒次数的相关性。当最近的饮酒直接占在多元回归，GM体积的双侧背外侧前额叶皮质（DLPFC）与酒精预期的组合样本呈正相关。据我们所知，这些结果是第一个确定酒精预期及其对饮酒行为的介导的结构性大脑相关性。这些发现表明，需要更多的研究来调查额叶皮质中GM体积的增加与酒精预期的神经相关性。
Alcohol use and misuse is known to involve structural brain changes. Numerous imaging studies have examined changes in gray matter (GM) volumes in dependent drinkers, but there is little information on whether non-dependent drinking is associated with structural changes and whether these changes are related to psychological factors – such as alcohol expectancy – that influence drinking behavior. We used voxel based morphometry (VBM) to examine whether the global positive scale of alcohol expectancy, as measured by the Alcohol Expectancy Questionnaire AEQ-3, is associated with specific structural markers and whether such markers are associated with drinking behavior in 113 adult non-dependent drinkers (66 women). Alcohol expectancy is positively correlated with GM volume of left precentrral gyrus (PCG) in men and women combined and bilateral superior frontal gyri (SFG) in women, and negatively correlated with GM volume of the right ventral putamen in men. Furthermore, mediation analyses showed that the GM volume of PCG mediate the correlation of alcohol expectancy and the average number of drinks consumed per occasion and monthly total number of drinks in the past year. When recent drinking was directly accounted for in multiple regressions, GM volume of bilateral dorsolateral prefrontal cortices (DLPFC) correlated positively with alcohol expectancy in the combined sample. To our knowledge, these results are the first to identify the structural brain correlates of alcohol expectancy and its mediation of drinking behaviors. These findings suggest that more studies are needed to investigate increased GM volume in the frontal cortices as a neural correlate of alcohol expectancy.
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影响因子：
3.4
作者：
Cranford, James A.;Zucker, Robert A.;Jester, Jennifer M.;Puttler, Leon I.;Fitzgerald, Hiram E.
通讯作者：
Fitzgerald, Hiram E.
DOI：
10.3109/00952991003736397
发表时间：
2010-05
期刊：
The American journal of drug and alcohol abuse
影响因子：
--
作者：
Hanson KL;Medina KL;Nagel BJ;Spadoni AD;Gorlick A;Tapert SF
通讯作者：
Tapert SF
影响因子：
5.9
作者：
BROWN, SA;GOLDMAN, MS;CHRISTIANSEN, BA
通讯作者：
CHRISTIANSEN, BA
影响因子：
2.8
作者：
Caldwell, LC;Schweinsburg, AD;Tapert, SF
通讯作者：
Tapert, SF
DOI：
10.1111/j.1530-0277.2011.01672.x
发表时间：
2012-05
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Bednarski SR;Erdman E;Luo X;Zhang S;Hu S;Li CS
通讯作者：
Li CS