Pattern of distribution of serotonergic fibers to the amygdala and extended amygdala in the rat.
Pattern of distribution of serotonergic fibers to the amygdala and extended amygdala in the rat.
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DOI：
10.1002/cne.24044
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发表时间：
2017-01-01
影响因子：
2.5
通讯作者：
Vertes, Robert P.
中科院分区：
文献类型：
--
作者：
Linley, Stephanie B.;Olucha-Bordonau, Francisco;Vertes, Robert P.
关键词：
众所周知，血清素能 (5-HT) 纤维广泛分布在整个前脑，包括杏仁核。尽管有一些报告检查了大鼠杏仁核选定核的 5-HT 神经支配，但之前没有报告描述过大鼠杏仁核的 5-HT 整体投射。使用血清素转运蛋白 SERT 的免疫染色，我们描述了 5-HT 纤维在大鼠中杏仁核（固有的）和延伸杏仁核的完整分布模式。根据其个体发生起源，杏仁核被细分为两个主要部分：大脑皮层和大脑皮层下部分，其中大脑皮层部分进一步分为浅核和深层核。 SERT+ 纤维被证明中度至密集地分布到深层和皮质大脑皮层核，但相比之下，轻微地分布到大脑皮层下核。具体来说，（1）深部大脑皮层核中，外侧核、基底外侧核和基底内侧核含有非常密集的5-HT纤维； (2) 皮质大脑皮层核、前皮质和杏仁核-皮质过渡区（吻部）以及后内侧和后外侧核（尾部）含有中等浓度的 5-HT 纤维； (3) 苍白下核、前核和内侧 (Me) 核的喙部含有中等浓度的 5-HT 纤维，而 Me 的尾部区域以及中央核和闰核含有稀疏/低浓度的 5-HT 纤维。关于延伸的杏仁核（主要是终纹床核，BST），总体而言，BST 包含适量的 5-HT 纤维，在整个 BST 中分布相当均匀。研究结果讨论了血清素对杏仁核的关键影响，特别是对基底复合体的影响，以及扩展杏仁核在控制恐惧和焦虑状态方面的影响。穿过杏仁核的头尾中部横切面，显示了血清素免疫反应性（SERT 阳性）纤维到杏仁核核的分布模式。如图所示，SERT+ 纤维大量终止于杏仁核的前基底外侧核和后基底外侧核（BLAa 和 BLAp），这与稀疏分布到 BLA 背内侧的杏仁核中央核形成对比。
As well recognized, serotonergic (5-HT) fibers distribute widely throughout the forebrain, including the amygdala. Although a few reports have examined the 5-HT innervation of select nuclei of the amygdala in the rat, no previous report has described overall 5-HT projections to the amygdala in the rat. Using immunostaining for the serotonin transporter, SERT, we describe the complete pattern of distribution of 5-HT fibers to the amygdala (proper) and to the extended amygdala in the rat. Based on its ontogenetic origins, the amygdalar was subdivided into two major parts: pallial and subpallial components, with the pallial component further divided into superficial and deep nuclei. SERT+ fibers were shown to distribute moderately to densely to the deep and cortical pallial nuclei, but, by contrast, lightly to the subpallial nuclei. Specifically, (1) of the deep pallial nuclei, the lateral, basolateral and basomedial nuclei contained a very dense concentration of 5-HT fibers; (2) of the cortical pallial nuclei, the anterior cortical and amygdala-cortical transition zone, rostrally, and the posteromedial and posterolateral nuclei, caudally, contained a moderate concentration of 5-HT fibers; and (3) of the subpallial nuclei, the anterior nuclei and the rostral part of the medial (Me) nuclei contained a moderate concentration of 5-HT fibers, whereas caudal regions of Me as well as the central nuclei and the intercalated nuclei contained a sparse/light concentration of 5-HT fibers. Regarding the extended amygdala (primarily the bed nucleus of stria terminalis, BST), on the whole, the BST contained moderate numbers of 5-HT fibers, spread fairly uniformly throughout BST. The findings were discussed with respect to a critical serotonergic influence on the amygdala, particularly on the basal complex, and extended amygdala in the control of states of fear and anxiety. Transverse section mid-rostrocaudally through the amygdala showing the pattern of distribution of serotonin-immunoreactive (SERT-positive) fibers to nuclei of the amygdala. As depicted, SERT+ fibers terminate heavily in the anterior and posterior basolateral nucleus of amygdala (BLAa and BLAp), which contrasts with the sparse distribution to the central nucleus of amygdala, dorsomedial to BLA.
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影响因子：
3.1
作者：
Bienkowski, Michael S.;Rinaman, Linda
通讯作者：
Rinaman, Linda
影响因子：
10.6
作者：
Christianson, John P.;Ragole, Thomas;Amat, Jose;Greenwood, Benjamin N.;Strong, Paul V.;Paul, Evan D.;Fleshner, Monika;Watkins, Linda R.;Maier, Steven F.
通讯作者：
Maier, Steven F.
在大鼠和人类中持续的恐惧：恐惧与焦虑中的杏仁核的作用。
DOI：
10.1038/npp.2009.109
发表时间：
2010-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
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影响因子：
16.2
作者：
Duvarci S;Pare D
通讯作者：
Pare D
影响因子：
26.1
作者：
Boukhris, Takoua;Sheehy, Odile;Berard, Anick
通讯作者：
Berard, Anick