5-hydroxytryptamine 2C receptors in the basolateral amygdala are involved in the expression of anxiety after uncontrollable traumatic stress.
5-hydroxytryptamine 2C receptors in the basolateral amygdala are involved in the expression of anxiety after uncontrollable traumatic stress.
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DOI：
10.1016/j.biopsych.2009.09.011
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发表时间：
2010-02-15
影响因子：
10.6
通讯作者：
Maier, Steven F.
中科院分区：
文献类型：
--
作者：
Christianson, John P.;Ragole, Thomas;Amat, Jose;Greenwood, Benjamin N.;Strong, Paul V.;Paul, Evan D.;Fleshner, Monika;Watkins, Linda R.;Maier, Steven F.
暴露于无法控制的压力往往会增加人类和啮齿动物的焦虑样行为。在大鼠中，这种效应取决于中缝背核（DRN）内的应激诱导的活动。然而，5-羟色胺在DRN投射区的作用在很大程度上是未知的。本研究的目的是：1）确定压力后焦虑测试期间DRN活性是否与焦虑样行为有关，2）评估焦虑测试期间无法控制的压力对基底外侧杏仁核细胞外5-羟色胺的影响，3）确定5-羟色胺2C受体（5-HT 2C）在无法控制的压力诱导的焦虑中的作用。大鼠暴露于无法控制的尾震。第二天，在JSE测试中评估焦虑样行为。BLA细胞外5-羟色胺浓度进行了评估，在JSE在体内微透析24小时后，不可控制的压力，可控的压力或没有压力。在单独的实验中，在JSE测试之前施用药物以抑制DRN或阻断5-HT 2C受体。暴露于无法控制的震惊减少了后来的社会探索。在社会探索过程中，先前无法控制的压力增强了BLA中的5-羟色胺流出，但可控的压力没有。DRN内8-OH-DPAT和全身和BLA内5-HT 2C受体拮抗剂SB 242084阻止了失控应激大鼠增强焦虑的表达。BLA内注射5-HT 2C激动剂CP 809101模拟应激的作用。这些结果表明，在不可控制的压力后观察到的焦虑样行为是由作用于BLA 5-HT 2C受体的夸大的5-HT介导的。
Exposure to uncontrollable stressors often increases anxiety-like behavior in both humans and rodents. In rat, this effect depends upon stress-induced activity within the dorsal raphé nucleus (DRN). However, the role of serotonin in DRN projection regions is largely unknown. The goals of the current study were to 1) determine if DRN activity during a post-stress anxiety test is involved in anxiety-like behavior, 2) assess the effect of uncontrollable stress on extracellular serotonin in the basolateral amygdala during the anxiety test, and 3) determine the role of the serotonin 2C receptor (5-HT2C) in uncontrollable stress-induced anxiety. Rats were exposed to tailshocks that were uncontrollable. On the following day anxiety-like behavior was assessed in a JSE test. BLA extracellular serotonin concentrations were assessed during JSE by in vivo microdialysis 24 h after uncontrollable stress, controllable stress or no stress. In separate experiments drugs were administered before the JSE test to inhibit the DRN or to block 5-HT2C receptors. Exposure to uncontrollable shock reduced later social exploration. Prior uncontrollable stress potentiated serotonin efflux in the BLA during social exploration, but controllable stress did not. Intra-DRN 8-OH-DPAT and systemic and intra-BLA 5-HT2C receptor antagonist SB 242084 prevented the expression of potentiated anxiety in uncontrollably stressed rats. Intra-BLA injection of the 5-HT2C agonist CP 809101 mimicked the effect of stress. These results suggest that the anxiety-like behavior observed after uncontrollable stress is mediated by exaggerated 5-HT acting at BLA 5-HT2C receptors.
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DOI：
10.1017/s1461145701002632
发表时间：
2001-12-01
影响因子：
4.8
作者：
Bagdy, G;Graf, M;Kantor, S
通讯作者：
Kantor, S
影响因子：
--
作者：
KESSLER, RC;SONNEGA, A;NELSON, CB
通讯作者：
NELSON, CB
中缝背核中 5-HT1A 自身受体的激活可减少社交失败的行为后果。
影响因子：
3.7
作者：
Cooper, Matthew A.;McIntyre, Kathleen E.;Huhman, Kim L.
通讯作者：
Huhman, Kim L.
影响因子：
3.2
作者：
Davis, L L;English, B A;Petty, F
通讯作者：
Petty, F
影响因子：
10.6
作者：
Lanzenberger, Rupert R.;Mitterhauser, Markus;Tauscher, Johannes
通讯作者：
Tauscher, Johannes