Modular synthesis of dihydro-isoquinolines: palladium-catalyzed sequential C(sp(2))-H and C(sp(3))-H bond activation.
Modular synthesis of dihydro-isoquinolines: palladium-catalyzed sequential C(sp(2))-H and C(sp(3))-H bond activation.
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DOI：
10.1039/c5sc01482d
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发表时间：
2015-10-01
期刊：
影响因子：
8.4
通讯作者：
Huang J
中科院分区：
文献类型：
--
作者：
Liu W;Yu Q;Hu L;Chen Z;Huang J
An efficient synthesis of dihydro-isoquinolines via a Pd–catalyzed double C–H bond activation/annulation featuring a short reaction time, high atom economy and the formation of a sterically less favoured tertiary C–N bond. An efficient synthesis of dihydro-isoquinolines via a Pd–catalyzed double C–H bond [a C(sp2)–H and a C(sp3)–H bond] activation/annulation (CHAA) reaction is presented. This methodology features a short reaction time, high atom economy (loss of H2O only) and the formation of a sterically less favoured tertiary C–N bond. This fast (30 min) and environmentally benign radical C–H activation approach has demonstrated the potential direction for the future design/development of fast and efficient C–H direct functionalization processes.
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影响因子：
16.6
作者：
Yan, Jia-Xuan;Li, Hu;Shi, Zhang-Jie
通讯作者：
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影响因子：
15
作者：
Gong, Wei;Zhang, Guofu;Liu, Tao;Giri, Ramesh;Yu, Jin-Quan
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Yu, Jin-Quan
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Huang, Jianhui
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作者：
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