Spatial patterns of correlation between cortical amyloid and cortical thickness in a tertiary clinical population with memory deficit.
Spatial patterns of correlation between cortical amyloid and cortical thickness in a tertiary clinical population with memory deficit.
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DOI：
10.1038/s41598-020-77503-2
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发表时间：
2020-11-26
影响因子：
4.6
通讯作者：
Jones SE
中科院分区：
文献类型：
--
作者：
Pillai JA;Larvie M;Chen J;Crawford A;Cummings JL;Jones SE
为了在临床上估计局部阿尔茨海默病（AD）的病理负担，需要能够用磁共振成像（MRI）测量跟踪脑淀粉样蛋白或tau正电子发射断层扫描（PET）的分析方法。因此，我们开发了一种强大的MRI分析方法，以识别在一致的PET图像中与区域淀粉样蛋白负荷线性相关的大脑区域。该方法通过全脑建模、非线性图像共配和部分体积校正，减少数据方差，提高皮质厚度-淀粉样蛋白相关性检测的灵敏度。利用这种方法，我们对75名三级记忆临床AD患者进行了横断面分析，以验证我们的假设，即区域淀粉样蛋白负荷和皮层厚度在内侧颞叶新皮层区域呈负相关。内侧颞皮质厚度与其区域淀粉样蛋白负荷不相关，而外侧颞、外侧顶叶和额叶皮质厚度与淀粉样蛋白负荷呈负相关。这项研究证明了我们的技术结合了全脑建模、非线性图像共配准和部分体积校正来跟踪特定大脑区域淀粉样蛋白负荷和皮层变薄之间的差异相关性的鲁棒性。该方法可用于淀粉样蛋白和tau PET评估相应的皮质厚度变化。
To estimate regional Alzheimer disease (AD) pathology burden clinically, analysis methods that enable tracking brain amyloid or tau positron emission tomography (PET) with magnetic resonance imaging (MRI) measures are needed. We therefore developed a robust MRI analysis method to identify brain regions that correlate linearly with regional amyloid burden in congruent PET images. This method was designed to reduce data variance and improve the sensitivity of the detection of cortical thickness–amyloid correlation by using whole brain modeling, nonlinear image coregistration, and partial volume correction. Using this method, a cross-sectional analysis of 75 tertiary memory clinic AD patients was performed to test our hypothesis that regional amyloid burden and cortical thickness are inversely correlated in medial temporal neocortical regions. Medial temporal cortical thicknesses were not correlated with their regional amyloid burden, whereas cortical thicknesses in the lateral temporal, lateral parietal, and frontal regions were inversely correlated with amyloid burden. This study demonstrates the robustness of our technique combining whole brain modeling, nonlinear image coregistration, and partial volume correction to track the differential correlation between regional amyloid burden and cortical thinning in specific brain regions. This method could be used with amyloid and tau PET to assess corresponding cortical thickness changes.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
3.7
作者：
Dickerson, Bradford C.;Bakkour, Akram;Salat, David H.;Feczko, Eric;Pacheco, Jenni;Greve, Douglas N.;Grodstein, Fran;Wright, Christopher I.;Blacker, Deborah;Rosas, H. Diana;Sperling, Reisa A.;Atri, Alireza;Growdon, John H.;Hyman, Bradley T.;Morris, John C.;Fischl, Bruce;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
3.2
作者：
Busovaca E;Zimmerman ME;Meier IB;Griffith EY;Grieve SM;Korgaonkar MS;Williams LM;Brickman AM
通讯作者：
Brickman AM
影响因子：
3.7
作者：
Arnold, Steven E.;Hyman, Bradley T.;Van Hoesen, Gary W.
通讯作者：
Van Hoesen, Gary W.
影响因子：
4.8
作者：
Fan LY;Tzen KY;Chen YF;Chen TF;Lai YM;Yen RF;Huang YY;Shiue CY;Yang SY;Chiu MJ
通讯作者：
Chiu MJ