Substantia nigra volume loss before basal forebrain degeneration in early Parkinson disease.
Substantia nigra volume loss before basal forebrain degeneration in early Parkinson disease.
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DOI：
10.1001/jamaneurol.2013.597
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发表时间：
2013-03
期刊：
影响因子：
29
通讯作者：
Corkin S
中科院分区：
文献类型：
--
作者：
Ziegler DA;Wonderlick JS;Ashourian P;Hansen LA;Young JC;Murphy AJ;Koppuzha CK;Growdon JH;Corkin S
为验证帕金森病(PD)患者黑质致密部(SNC)变性先于胆碱能基底前脑(BF)变性的假设，采用新的多光谱结构磁共振(MR)成像工具测量SNC和BF体积。配对病例对照研究。麻省理工学院麦戈文脑研究所的阿蒂努拉·A·马蒂诺斯成像中心，以及麻省总医院/麻省理工学院莫里斯·尤德尔帕金森病研究卓越中心。参与者包括29名帕金森病患者(Hoehn和Yahr[H&Y]1-3期)和27名匹配的健康对照组。我们从每个参与者那里获得了MultiECHO T1加权、MultiECHO质子密度、T2加权和T2加权流体衰减反转恢复(FLAIR)序列。对于SNC，我们创建了多个回声的加权平均值，产生了具有高对比度与噪声比的单个体积。我们使用T2加权FLAIR图像对高炉进行可视化处理。对于每个参与者，我们手动标记了两个结构并计算了它们的体积。与对照组相比，13例H&Y期PD患者的SNC体积显著减少。16例H&Y分期为2或3PD的患者几乎没有额外的容量损失。相反，BF容量丢失出现的时间较晚，与对照组和H&Y 1期PD患者相比，H&Y期2或3期PD患者的BF容量明显减少。后一组与对照组没有显著差异。我们的结果支持帕金森病的神经病理轨迹，并建立了新的多光谱方法作为追踪SNC和BF退变的MR成像生物标志物。
To test the hypothesis that degeneration of the substantia nigra pars compacta (SNc) precedes that of the cholinergic basal forebrain (BF) in Parkinson disease (PD) using new multispectral structural magnetic resonance (MR) imaging tools to measure the volumes of the SNc and BF. Matched case-control study. The Athinoula A. Martinos Imaging Center at the McGovern Institute for Brain Research, Massachusetts Institute of Technology (MIT), and the Massachusetts General Hospital/MIT Morris Udall Center of Excellence in Parkinson Disease Research. Participants included 29 patients with PD (Hoehn and Yahr [H&Y] stages 1–3) and 27 matched healthy control subjects. We acquired multiecho T1-weighted, multiecho proton density, T2-weighted, and T2-weighted fluid-attenuated inversion recovery (FLAIR) sequences from each participant. For the SNc, we created a weighted mean of the multiple echoes, yielding a single volume with a high ratio of contrast to noise. We visualized the BF using T2-weighted FLAIR images. For each participant, we manually labeled the 2 structures and calculated their volumes. Relative to the controls, 13 patients with H&Y stage 1 PD had significantly decreased SNc volumes. Sixteen patients with H&Y stage 2 or 3 PD showed little additional volume loss. In contrast, the BF volume loss occurred later in the disease, with a significant decrease apparent in patients having H&Y stage 2 or 3 PD compared with the controls and the patients having H&Y stage 1 PD. The latter group did not differ significantly from the controls. Our results support the proposed neuropathological trajectory in PD and establish novel multispectral methods as MR imaging biomarkers for tracking the degeneration of the SNc and BF.
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影响因子：
4.2
作者：
George S;Mufson EJ;Leurgans S;Shah RC;Ferrari C;deToledo-Morrell L
通讯作者：
deToledo-Morrell L
影响因子：
12.7
作者：
Halliday, Glenda;Hely, Mariese;Morris, John
通讯作者：
Morris, John
影响因子：
9.9
作者：
Gilman, S.;Koeppe, R. A.;Bhaumik, A.
通讯作者：
Bhaumik, A.
DOI：
10.1076/jcen.25.1.94.13624
发表时间：
2003-02-01
影响因子：
2.2
作者：
Locascio, JJ;Corkin, S;Growdon, JH
通讯作者：
Growdon, JH
影响因子：
4.2
作者：
Choi, Seo Hee;Jung, Tae Min;Lee, Phil Hyu
通讯作者：
Lee, Phil Hyu