Hippocampal Neural Circuits Respond to Optogenetic Pacing of Theta Frequencies by Generating Accelerated Oscillation Frequencies.
Hippocampal Neural Circuits Respond to Optogenetic Pacing of Theta Frequencies by Generating Accelerated Oscillation Frequencies.
复制标题
海马神经回路通过产生加速振荡频率来响应theta频率的光遗传学起搏。
DOI：
10.1016/j.cub.2018.02.061
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发表时间：
2018-04-23
期刊：
影响因子：
--
通讯作者：
Leutgeb S
中科院分区：
文献类型：
--
作者：
Zutshi I;Brandon MP;Fu ML;Donegan ML;Leutgeb JK;Leutgeb S
生物振荡可以由一小群节律性起搏细胞控制，或者在大脑中，也可以从复杂的细胞和回路水平的相互作用中产生。这些机制是否以及如何结合起来产生控制认知功能的振荡模式还不清楚。例如，海马网络的活动在时间上由7-9 Hz局部场电位（LFP）θ节律协调，但许多个体细胞与LFP频率解耦，以高约1 Hz的频率振荡。为了更好地理解产生这些复杂振荡模式的网络相互作用，我们询问当LFP频率被实验扰动时，LFP和单个细胞之间的相对频率差是否被保留。我们发现，内侧隔GABA能神经元的节律性光遗传学刺激控制海马LFP频率在内源性θ范围之外，即使在内源性机制本来会产生7-9 Hz θ振荡的行为状态期间。虽然LFP频率与光遗传学诱导的刺激频率相匹配，但单个海马细胞的振荡频率仍然广泛分布，并且在包括中间神经元在内的细胞子集中，振荡频率加速超过新的基础LFP频率。因此，从隔GABA能神经元到海马的输入似乎并不直接控制细胞振荡频率，而是参与加速单个细胞节律性的细胞和回路机制。因此，θ振荡是皮层振荡的一个例子，它将来自皮层下起搏器的联合收割机输入与局部计算相结合，以生成支持认知功能的复杂振荡模式。
Biological oscillations can be controlled by a small population of rhythmic pacemaker cells, or in the brain, also emerge from complex cellular and circuit-level interactions. Whether and how these mechanisms are combined to give rise to oscillatory patterns that govern cognitive function is not well understood. For example, the activity of hippocampal networks is temporally coordinated by a 7–9 Hz local field potential (LFP) theta rhythm, yet many individual cells decouple from the LFP frequency to oscillate at frequencies ~1 Hz higher. To better understand the network interactions that produce these complex oscillatory patterns, we asked whether the relative frequency difference between LFP and individual cells is retained when the LFP frequency is perturbed experimentally. We found that rhythmic optogenetic stimulation of medial septal GABAergic neurons controlled the hippocampal LFP frequency outside of the endogenous theta range, even during behavioral states when endogenous mechanisms would otherwise have generated 7–9 Hz theta oscillations. While the LFP frequency matched the optogenetically induced stimulation frequency, the oscillation frequency of individual hippocampal cells remained broadly distributed, and in a subset of cells, including interneurons, was accelerated beyond the new base LFP frequency. The inputs from septal GABAergic neurons to the hippocampus therefore do not appear to directly control the cellular oscillation frequency but rather engage cellular and circuit mechanisms that accelerate the rhythmicity of individual cells. Theta oscillations are therefore an example of cortical oscillations that combine inputs from a subcortical pacemaker with local computations to generate complex oscillatory patterns that support cognitive functions.
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影响因子：
16.2
作者：
Joshi A;Salib M;Viney TJ;Dupret D;Somogyi P
通讯作者：
Somogyi P
DOI：
10.1073/pnas.0912478107
发表时间：
2010-04-27
影响因子：
11.1
作者：
Geisler, Caroline;Diba, Kamran;Buzsaki, Gyoergy
通讯作者：
Buzsaki, Gyoergy
影响因子：
5.3
作者：
Jaramillo, Jorge;Schmidt, Robert;Kempter, Richard
通讯作者：
Kempter, Richard
影响因子：
16.2
作者：
Fuhrmann, Falko;Justus, Daniel;Remy, Stefan
通讯作者：
Remy, Stefan
影响因子：
56.9
作者：
Koenig, Julie;Linder, Ashley N.;Leutgeb, Stefan
通讯作者：
Leutgeb, Stefan