Occurrence, Distribution, and Risk Assessment of Perfluoroalkyl Acids (PFAAs) in Muscle and Liver of Cattle in Xinjiang, China.
Occurrence, Distribution, and Risk Assessment of Perfluoroalkyl Acids (PFAAs) in Muscle and Liver of Cattle in Xinjiang, China.
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中国新疆牛肌肉和肝脏中全氟烷基酸 (PFAA) 的存在、分布和风险评估
DOI：
10.3390/ijerph14090970
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发表时间：
2017-08-28
影响因子：
--
通讯作者：
Tong Y
中科院分区：
文献类型：
--
作者：
Wang G;Lu J;Xing Z;Li S;Liu Z;Tong Y
尽管全氟烷基酸（PFAAs）在许多地区存在风险，但对新疆的流行情况知之甚少。采用液相色谱-串联质谱联用技术，对新疆北方、南疆和东疆22个城市采集的293份牛肉和牛肝样品中13种PFAAs进行了检测。总的来说，与以前的研究相比，PFAA的平均值相对较低。肝脏中的全氟辛酸平均含量较高，为1.632 ng/g，是肌肉中的60倍以上（0.026 ng/g）。在分析的PFAAs中，中链化合物占主导地位，占总量的70%以上。全氟辛烷磺酸（PFOS）在肝脏中普遍存在，平均浓度最高（0.617纳克/克），检测频率最高（80%）。在比较新疆三个地区时，我们发现PFAA谱存在差异，其中北方地区的PFAA水平最高。此外，全氟辛烷磺酸和全氟辛酸的平均日摄入量和风险比因区域、城市/农村环境、性别、种族和年龄而异。13种PFAAs的最高风险值估计为0.837 × 10−3，远低于1，表明新疆食用牛肉和牛肝不存在健康风险。
Despite risks associated with perfluoroalkyl acids (PFAAs) in many regions, little is known about their prevalence in Xinjiang. We determined the presence of 13 PFAAs in 293 beef muscle and liver samples collected in 22 cities covering northern, southern, and eastern Xinjiang using liquid chromatography, coupled with tandem mass spectrometry. Overall, the average values for PFAAs were relatively low compared with previous studies. Liver presented higher mean levels of total PFAAs at 1.632 ng/g, which was over 60-fold higher than in muscle (0.026 ng/g). Among the PFAAs analyzed, medium-chain compounds were dominant, accounting for more than 70% of the total. Perfluorooctane sulfonate (PFOS) was highly prevalent in the liver with the highest mean concentration (0.617 ng/g) and detection frequency (80%). When comparing the three regions of Xinjiang, we found differences in PFAA profiles, with the northern region showing the highest levels. Furthermore, the average daily intake and hazard ratios of PFOS and perfluorooctanoic acid varied by region, urban/rural environment, gender, ethnicity, and age. The highest risk value of 13 PFAAs was estimated to be 0.837 × 10−3, which is far below 1, indicating that there is no health risk posed by eating beef muscle and liver in Xinjiang.
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