Placental transfer of persistent organic pollutants: a preliminary study on mother-newborn pairs.
Placental transfer of persistent organic pollutants: a preliminary study on mother-newborn pairs.
复制标题
持久性有机污染物的胎盘转移：母婴对的初步研究。
DOI：
10.3390/ijerph10020699
复制
发表时间：
2013-02-07
影响因子：
--
通讯作者：
De Felip E
中科院分区：
文献类型：
--
作者：
Porpora MG;Lucchini R;Abballe A;Ingelido AM;Valentini S;Fuggetta E;Cardi V;Ticino A;Marra V;Fulgenzi AR;De Felip E
本研究的目的是表征胎盘转移的一些环境污染物，并探讨定量预测在子宫内暴露于这些污染物的浓度在母体血液中评估的可能性。对生活在罗马的38名孕妇的血清样本和她们各自新生儿的脐带血样本中的有毒物质，如农药（p，p'-DDE、β-HCH和HCB）、多氯联苯（PCBs）、全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA）的水平进行了测定。该研究于2008 - 2009年进行。母体血清和脐带血清中PCB的平均浓度分别为0.058~0.30和0.018~0.064ng/g·fw。母亲和新生儿体内全氟辛烷磺酸和全氟辛酸浓度的算术平均值分别为3.2和1.4纳克/克·fw，以及2.9和1.6纳克/克·fw。观察到母体和胎儿体内的全氟辛烷磺酸浓度之间存在很强的相关性（斯皮尔曼r = 0.74，p <0.001），全氟辛酸（斯皮尔曼r = 0.70，p <0.001），PCB 153（斯皮尔曼r = 0.60，p <0.001）、HCB（斯皮尔曼r = 0.68，p <0.001）、PCB 180（斯皮尔曼r = 0.55，p = 0.0012）和p，p'-DDE（斯皮尔曼r = 0.53，p = 0.0099）。多氯联苯118和138之间的相关性很弱（p <0.1）。
The aim of this study was to characterize the placental transfer of some environmental pollutants, and to explore the possibility of quantitatively predicting in utero exposure to these contaminants from concentrations assessed in maternal blood. Levels of toxic substances such as pesticides (p,p’-DDE, β-HCH, and HCB), polychlorinated biphenyls (PCBs), perfluorooctane sulfonate (PFOS), and perfluorooctanoic acid (PFOA) were determined in serum samples of 38 pregnant women living in Rome and in samples of cord blood from their respective newborns. The study was carried out in the years 2008–2009. PCB mean concentrations in maternal serum and cord serum ranged from 0.058 to 0.30, and from 0.018 to 0.064 ng/g·fw respectively. Arithmetic means of PFOS and PFOA concentrations in mothers and newborns were 3.2 and 1.4 ng/g·fw, and 2.9 and 1.6 ng/g·fw. A strong correlation was observed between concentrations in the maternal and the foetal compartment for PFOS (Spearman r = 0.74, p < 0.001), PFOA (Spearman r = 0.70, p < 0.001), PCB 153 (Spearman r = 0.60, p < 0.001), HCB (Spearman r = 0.68, p < 0.001), PCB 180 (Spearman r = 0.55, p = 0.0012), and p,p’-DDE (Spearman r = 0.53, p = 0.0099). A weak correlation (p < 0.1) was observed for PCBs 118 and 138.
登录
查看更多内容
影响因子：
11.4
作者：
Fromme, Hermann;Mosch, Christine;Volkel, Wolfgang
通讯作者：
Volkel, Wolfgang
影响因子：
10.4
作者：
Fei C;McLaughlin JK;Lipworth L;Olsen J
通讯作者：
Olsen J
影响因子：
3.4
作者：
Gilbert, Mary E.;Rovet, Joanne;Koibuchi, Noriyuki
通讯作者：
Koibuchi, Noriyuki
影响因子：
3.8
作者：
Cohn, Barbara A.;Terry, Mary Beth;Plumb, Marj;Cirillo, Piera M.
通讯作者：
Cirillo, Piera M.
影响因子：
10.4
作者：
Joensen UN;Bossi R;Leffers H;Jensen AA;Skakkebaek NE;Jørgensen N
通讯作者：
Jørgensen N