Resting-state connectivity of the amygdala is altered following Pavlovian fear conditioning.
Resting-state connectivity of the amygdala is altered following Pavlovian fear conditioning.
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杏仁核的静止状态连通性在帕夫洛维亚恐惧调节后会改变。
DOI：
10.3389/fnhum.2012.00242
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发表时间：
2012
影响因子：
2.9
通讯作者：
Helmstetter FJ
中科院分区：
文献类型：
--
作者：
Schultz DH;Balderston NL;Helmstetter FJ
在巴甫洛夫恐惧条件反射中，杏仁核的神经可塑性对于记忆的获取和储存是必要的，但大多数神经影像学研究只关注条件反射过程中的刺激诱发反应。本研究考察了巴甫洛夫恐惧条件反射（一项情绪学习任务）前后杏仁核静息状态功能连接（RSFC）的变化。条件反射的行为结果显示，参与者学习正常，学习过程中记录的fMRI数据发现了许多刺激诱发的变化，这与之前的研究一致。对条件反射前和条件反射后杏仁核连通性的直接比较显示，在条件反射后，额上回的前额叶皮层背侧（PFC）区域的连通性显著增加。外显记忆表现的行为测量与额上回相邻区域内杏仁核连通性的变化呈正相关。此外，内隐自主调节测量与杏仁核和前扣带皮层（ACC）之间连通性的变化呈正相关。静息状态数据显示，在巴甫洛夫恐惧条件反射之后，杏仁核的连通性发生了改变，而这些变化也与行为结果有关。这些变化可能反映了一个巩固过程的运作，该过程在学习事件发生后加强了神经连接以支持记忆。
Neural plasticity in the amygdala is necessary for the acquisition and storage of memory in Pavlovian fear conditioning, but most neuroimaging studies have focused only on stimulus-evoked responses during the conditioning session. This study examined changes in the resting-state functional connectivity (RSFC) of the amygdala before and after Pavlovian fear conditioning, an emotional learning task. Behavioral results from the conditioning session revealed that participants learned normally and fMRI data recorded during learning identified a number of stimulus-evoked changes that were consistent with previous work. A direct comparison between the pre- and post-conditioning amygdala connectivity revealed a region of dorsal prefrontal cortex (PFC) in the superior frontal gyrus that showed a significant increase in connectivity following the conditioning session. A behavioral measure of explicit memory performance was positively correlated with the change in amygdala connectivity within a neighboring region in the superior frontal gyrus. Additionally, an implicit autonomic measure of conditioning was positively correlated with the change in connectivity between the amygdala and the anterior cingulate cortex (ACC). The resting-state data show that amygdala connectivity is altered following Pavlovian fear conditioning and that these changes are also related to behavioral outcomes. These alterations may reflect the operation of a consolidation process that strengthens neural connections to support memory after the learning event.
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