Neural substrates of explicit and implicit fear memory.

Neural substrates of explicit and implicit fear memory.
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DOI:
10.1016/j.neuroimage.2008.11.015
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发表时间:
2009-03-01
期刊:
影响因子:
5.7
通讯作者:
Bandettini PA
Bandettini PA
中科院分区:
医学1区
文献类型:
--
作者:
Knight DC;Waters NS;Bandettini PA

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我们恐惧经历的不同方面似乎是由独立的外显记忆和内隐记忆过程介导的。为了识别支持这些独立记忆过程的大脑区域,我们测量了巴甫洛夫恐惧条件反射过程中的应急意识,条件性恐惧表达和功能性磁共振成像信号,其中预测厌恶事件的音调以阈上和阈下音量呈现。仅在感知条件反射试验中,与学习相关的海马和海马旁活动一起开发了应急意识。相比之下,条件性恐惧和杏仁核活动的差异发展的感知和未感知的试验,无论是否表达的应急意识。这些发现证明了这些大脑区域在外显和内隐恐惧记忆过程中的不同作用。
Distinct aspects of our fearful experiences appear to be mediated by separate explicit and implicit memory processes. To identify brain regions that support these separate memory processes, we measured contingency awareness, conditional fear expression, and functional magnetic resonance imaging signal during a Pavlovian fear conditioning procedure in which tones that predicted an aversive event were presented at supra and sub-threshold volumes. Contingency awareness developed in conjunction with learning-related hippocampal and parahippocampal activity on perceived conditioning trials only. In contrast, conditional fear and differential amygdala activity developed on both perceived and unperceived trials, regardless of whether contingency awareness was expressed. These findings demonstrate the distinct roles of these brain regions in explicit and implicit fear memory processes.
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发表时间: 1999-10-25
期刊: COGNITIVE BRAIN RESEARCH
影响因子: --
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