Innervation patterns of autonomic axons in the human endocrine pancreas.
Innervation patterns of autonomic axons in the human endocrine pancreas.
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DOI：
10.1016/j.cmet.2011.05.008
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发表时间：
2011-07-06
期刊：
影响因子：
29
通讯作者：
Caicedo A
中科院分区：
文献类型：
--
作者：
Rodriguez-Diaz R;Abdulreda MH;Formoso AL;Gans I;Ricordi C;Berggren PO;Caicedo A
自主神经系统调节内分泌胰腺（胰岛）的激素分泌，从而影响葡萄糖代谢。副交感神经和交感神经支配胰岛，但确切的神经支配模式尚不清楚，特别是在人类胰岛中。在这里，我们表明，人类胰岛的神经支配是不同的小鼠胰岛，它不符合现有的模型的自主控制胰岛功能。通过三维可视化轴突和量化胰岛内的轴突密度和接触，我们发现，与小鼠内分泌细胞相比，人类内分泌细胞与自主轴突稀疏接触。很少有副交感神经胆碱能轴突穿透人体胰岛，侵入的交感神经纤维优先神经支配位于胰岛内的血管的平滑肌细胞。因此，交感神经不是直接调节内分泌细胞功能，而是通过控制局部血流或作用于位于下游的胰岛区域来调节人类胰岛中的激素分泌。
The autonomic nervous system regulates hormone secretion from the endocrine pancreas, the islets of Langerhans, and thus impacts glucose metabolism. The parasympathetic and sympathetic nerves innervate the pancreatic islet, but the precise innervation patterns are not known, particularly in human islets. Here we demonstrate that the innervation of human islets is different from that of mouse islets and that it does not conform to existing models of autonomic control of islet function. By visualizing axons in three dimensions and quantifying axonal densities and contacts within pancreatic islets, we found that, in contrast to mouse endocrine cells, human endocrine cells are sparsely contacted by autonomic axons. Few parasympathetic cholinergic axons penetrate the human islet and the invading sympathetic fibers preferentially innervate smooth muscle cells of blood vessels located within the islet. Thus, rather than modulating endocrine cell function directly, sympathetic nerves may regulate hormone secretion in human islets by controlling local blood flow or by acting on islet regions located downstream.
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影响因子：
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作者：
JANSSON, L;HELLERSTROM, C
通讯作者：
HELLERSTROM, C
影响因子：
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影响因子：
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作者：
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通讯作者：
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