Association of three SNPs in interleukin-28B with graft hepatic dysfunction after liver transplantation in Chinese Han population.
Association of three SNPs in interleukin-28B with graft hepatic dysfunction after liver transplantation in Chinese Han population.
复制标题
白细胞介素28B中的三个SNP与中国汉族人群肝移植后移植肝功能障碍的关系。
DOI：
10.1016/j.gene.2012.07.065
复制
发表时间：
2012-10
期刊：
影响因子：
3.5
通讯作者：
Zhang, Junlong
中科院分区：
文献类型：
--
作者：
Chen, Jie;Li, Yi;Wang, Lanlan;Fu, Yang;Liao, Yun;Zhang, Junlong
移植物反复感染限制了LT的效果，早期识别和预防HBV复发非常重要，目的探讨白细胞介素28 B（IL-28 B）基因单核苷酸多态性（SNPs）与肝移植术后移植物再感染的关系。复发和157例无HBV复发的受者。我们采用HRM分析（高分辨率熔解曲线分析）对IL-28 B基因启动子区rs 12979860、rs 12980275和rs 8099917三个位点的SNPs进行了研究。结论IL-28 B基因多态性可能与肝移植受者的预后有关，但尚需进一步研究。
BACKGROUNDRecurrent graft infection limited the effect of LT, early recognition and prophylaxis of HBV recurrence are very important, and interleukin 28B (IL‐28B) gene was reported to be associated with HBV infection.AIMSTo explore the association between IL-28B single-nucleotide polymorphisms (SNPs) and graft re-infection after liver transplantation(LT).METHODS21 recipients with hepatitis B virus(HBV) recurrence and 157 recipients without HBV recurrence were included. We studied three SNPs in the promoter region of IL-28B gene at the positions rs12979860, rs12980275 and rs8099917 by HRM analysis (high-resolution melting curve analysis).RESULTSHepatic allograft dysfunction was more likely to be associated with IL-28B SNPs. However, there was no significant difference in the frequencies of IL-28B gene distribution in recipients with or without HBV recurrence.CONCLUSIONIL-28B gene polymorphism may be associated with the prognosis of LT recipients but it needs more experiments.
登录
查看更多内容
影响因子：
6.7
作者：
A. Tsubota;N. Shimada;K. Yoshizawa;Tomomi Furihata;R. Agata;Yoko Yumoto;H. Abe;Makiko Ika;Y. Namiki;K. Chiba;K. Fujise;N. Tada;Y. Aizawa
通讯作者：
A. Tsubota;N. Shimada;K. Yoshizawa;Tomomi Furihata;R. Agata;Yoko Yumoto;H. Abe;Makiko Ika;Y. Namiki;K. Chiba;K. Fujise;N. Tada;Y. Aizawa
影响因子：
3.5
作者：
Magiorkinis, EN;Magiorkinis, GN;Hatzakis, AE
通讯作者：
Hatzakis, AE
影响因子：
3.7
作者：
Rembeck K;Alsiö A;Christensen PB;Färkkilä M;Langeland N;Buhl MR;Pedersen C;Mørch K;Westin J;Lindh M;Hellstrand K;Norkrans G;Lagging M
通讯作者：
Lagging M
影响因子：
2.8
作者：
Duan, Shaoqiong;Zhang, Guoyu;Xing, Fanfan
通讯作者：
Xing, Fanfan
影响因子：
--
作者：
Chu-ming Chen;F. Zhou;Yuanping Zhou;Yanli Zeng;Wei Li-;J. Hou
通讯作者：
Chu-ming Chen;F. Zhou;Yuanping Zhou;Yanli Zeng;Wei Li-;J. Hou