Dopamine and frontostriatal networks in cognitive aging.
Dopamine and frontostriatal networks in cognitive aging.
复制标题
认知衰老中的多巴胺和额叶网络。
DOI：
10.1016/j.neurobiolaging.2011.03.002
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发表时间：
2012-03
影响因子：
4.2
通讯作者：
Jagust WJ
中科院分区：
文献类型：
--
作者：
Klostermann EC;Braskie MN;Landau SM;O'Neil JP;Jagust WJ
Recent studies have linked dopamine to differences in behavior and brain activity in normal individuals. We explored these relationships in older and younger adults by investigating how functional connectivity between the striatum and prefrontal cortex is related to caudate dopamine and verbal working memory task performance. We studied 12 young and 18 older participants with functional magnetic resonance imaging (fMRI) during this task, and used positron emission tomography with the tracer 6-[18F]-fluoro-L-m-tyrosine (FMT) to assess dopamine synthesis capacity. Younger adults had a greater extent of frontal-caudate functional connectivity during the load-dependent delay period of the working memory task than the older participants. Across all subjects, the extent of this functional connectivity was negatively correlated with dopamine synthesis capacity, such that participants with the greatest connectivity had the lowest caudate FMT signal. Additionally, the extent of functional connectivity was positively correlated with working memory performance. Overall these data suggest interdependencies exist between fronto-striatal functional connectivity, dopamine, and working memory performance and that this system is functioning suboptimally in normal aging.
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影响因子：
4.2
作者：
Backman, Lars;Karlsson, Sari;Nyberg, Lars
通讯作者：
Nyberg, Lars
影响因子：
4.2
作者：
Kaasinen, V;Vilkman, H;Rinne, JO
通讯作者：
Rinne, JO
DOI：
10.1073/pnas.93.24.13534
发表时间：
1996-11-26
影响因子：
11.1
作者：
Gabrieli, JDE
通讯作者：
Gabrieli, JDE
影响因子：
11.2
作者：
Frey, KA;Koeppe, RA;Kuhl, DE
通讯作者：
Kuhl, DE
影响因子：
5.7
作者：
Chang, Catherine;Crottaz-Herbette, Sonia;Menon, Vinod
通讯作者：
Menon, Vinod