Cognitive training for improving executive function in chemotherapy-treated breast cancer survivors.
Cognitive training for improving executive function in chemotherapy-treated breast cancer survivors.
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DOI：
10.1016/j.clbc.2013.02.004
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发表时间：
2013-08
影响因子：
3.1
通讯作者：
Morrow G
中科院分区：
文献类型：
--
作者：
Kesler S;Hadi Hosseini SM;Heckler C;Janelsins M;Palesh O;Mustian K;Morrow G
思考和解决问题的困难在乳腺癌幸存者中很常见。我们针对 41 名乳腺癌幸存者测试了计算机化认知训练计划。培训计划与思维和解决问题能力的显着提高有关。我们的研究结果表明，我们的在线家庭认知训练计划有可能改善乳腺癌幸存者的认知困难。大多数乳腺癌（BC）幸存者，特别是那些接受化疗的患者，都会经历长期的认知缺陷，从而显着降低生活质量。最常受影响的认知领域包括执行功能 (EF)，例如工作记忆、认知灵活性、多任务处理、计划和注意力。此前针对其他人群的研究表明，认知训练（一种治疗认知缺陷的行为方法）可以显着改善包括 EF 在内的多种认知技能。在这项研究中，我们进行了一项随机对照试验，以调查针对长期 BC 幸存者的新型在线 EF 培训计划的可行性和初步有效性。共有 41 名 BC 幸存者（21 名活跃人员，20 名候补人员）在 12 周内完成了 48 节课程的培训计划。参与者平均接受治疗后 6 年。认知训练显着提高了认知灵活性、言语流畅性和处理速度，通过标准化测量评估，言语记忆的下游略有改善。与候补名单组相比，活跃组的 EF 技能（包括计划、组织和任务监控）自评也有所提高。我们的研究结果表明，即使是长期幸存者，通过使用计算机化的家庭干预计划也可以提高 EF 技能。这些改进可能包括主观 EF 技能，这表明将培训计划转移到现实世界的行为。
Difficulties with thinking and problem solving are very common among breast cancer survivors. We tested a computerized cognitive training program for 41 breast cancer survivors. The training program was associated with significant improvements in thinking and problem-solving skills. Our findings demonstrate potential for our online, home-based cognitive training program to improve cognitive difficulties among breast cancer survivors. A majority of breast cancer (BC) survivors, particularly those treated with chemotherapy, experience long-term cognitive deficits that significantly reduce quality of life. Among the cognitive domains most commonly affected include executive functions (EF), such as working memory, cognitive flexibility, multitasking, planning, and attention. Previous studies in other populations have shown that cognitive training, a behavioral method for treating cognitive deficits, can result in significant improvements in a number of cognitive skills, including EF. In this study, we conducted a randomized controlled trial to investigate the feasibility and preliminary effectiveness of a novel, online EF training program in long-term BC survivors. A total of 41 BC survivors (21 active, 20 wait list) completed the 48 session training program over 12 weeks. The participants were, on average, 6 years after therapy. Cognitive training led to significant improvements in cognitive flexibility, verbal fluency and processing speed, with marginally significant downstream improvements in verbal memory as assessed via standardized measures. Self-ratings of EF skills, including planning, organizing, and task monitoring, also were improved in the active group compared with the wait list group. Our findings suggest that EF skills may be improved even in long-term survivors by using a computerized, home-based intervention program. These improvements may potentially include subjective EF skills, which suggest a transfer of the training program to real-world behaviors.
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影响因子：
45.3
作者：
Ahles, Tim A.;Saykin, Andrew J.;Kaufman, Peter A.
通讯作者：
Kaufman, Peter A.
影响因子：
4.8
作者：
de Ruiter, Michiel B.;Reneman, Liesbeth;Schagen, Sanne B.
通讯作者：
Schagen, Sanne B.
影响因子：
--
作者：
Hong, David;Kent, Jamie Scaletta;Kesler, Shelli
通讯作者：
Kesler, Shelli
影响因子：
3.6
作者：
Ferguson, Robert J.;McDonald, Brenna C.;Rocque, Michael A.;Furstenberg, Charlotte T.;Horrigan, Susan;Ahles, Tim A.;Saykin, Andrew J.
通讯作者：
Saykin, Andrew J.
影响因子：
45.3
作者：
Deprez, Sabine;Amant, Frederic;Sunaert, Stefan
通讯作者：
Sunaert, Stefan