Correlation between peripheral white blood cell counts and hyperglycemic emergencies.
Correlation between peripheral white blood cell counts and hyperglycemic emergencies.
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DOI：
10.7150/ijms.6155
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发表时间：
2013
影响因子：
3.6
通讯作者：
Liu H
中科院分区：
文献类型：
--
作者：
Xu W;Wu HF;Ma SG;Bai F;Hu W;Jin Y;Liu H
目的：探讨白细胞分类计数与高血糖急症的相关性。研究方法：入选50例糖尿病酮症酸中毒（DKA）患者、50例糖尿病酮症（DK）患者、50例血糖控制稳定的非DK糖尿病患者和50例正常对照。在入院时和治疗后对他们的白细胞总数和分类计数进行测量和评估。结果如下：糖尿病酮症酸中毒和糖尿病酮症酸中毒患者的血糖水平较高（分别为20.84±6.73 mmol/L，15.55±2.6 mmol/L）和更多的中位白细胞（分别为13325/mm 3和6595/mm 3）和中性粒细胞中位数（分别为11124 /mm 3和4125/mm 3），但与非DK组和对照组相比，中值嗜酸性粒细胞更少（分别为28/mm 3和72/mm 3）（所有p < 0.05）。急性感染加重了病变的程度。DK和非DK患者的中位白细胞计数（分别为6595/mm 3和6008/mm 3）在正常范围内。重度DKA患者的总白细胞和中性粒细胞计数显著高于轻、中度DKA患者，而嗜酸性粒细胞计数显著低于轻、中度DKA患者（p < 0.05）。当DKA、DK和感染消退时，总白细胞和中性粒细胞下降，但嗜酸性粒细胞增加。总白细胞、中性粒细胞和单核细胞计数与动脉pH值水平呈负相关（r =-0.515，r =-0.510，r =-0.517，均P < 0.001），与血糖水平呈正相关DKA组与正常对照组比较，差异有统计学意义（r = 0.722，r = 0.733，r = 0.632，均P < 0.05）。动脉pH水平是影响DKA中总白细胞的最显著因素（β = 0.467，p = 0.003）。诊断分析表明，高白细胞和中性粒细胞计数和低嗜酸性粒细胞计数有显着的能力来反映高血糖急症的存在。结论：DKA和DK患者的总白细胞和中性粒细胞增多，而嗜酸性粒细胞减少。白细胞计数可增加反映高血糖危象和急性感染的有价值信息。
Objective: To determine the correlation between differential leukocyte counts and hyperglycemic emergencies. Methods: Fifty patients with diabetic ketoacidosis (DKA), 50 patients with diabetic ketosis (DK), 50 non-DK diabetic patients with stable glycemic control, and 50 normal controls were enrolled. Their total and differential leukocyte counts were measured and evaluated at admission and after treatment. Results: The patients with DKA and DK had higher plasma glucose levels (20.84±6.73 mmol/L, 15.55±2.6 mmol/L, respectively) and more median leukocytes (13325/mm3 and 6595/mm3, respectively) and median neutrophils (11124 /mm3 and 4125/mm3, respectively) but fewer median eosinophils (28/mm3 and 72/mm3, respectively) compared to non-DK and control groups (all p < 0.05). Acute infection increased the elevating extent. The median leukocyte counts in DK and non-DK patients (6595/mm3 and 6008/mm3, respectively) were within the normal range. The counts of total leukocytes and neutrophils were significantly higher but eosinophils lower in severe DKA cases than in mild/moderate cases (p < 0.05). When the DKA and DK and infection resolved, total leukocytes and neutrophils fell, but eosinophils increased. The counts of total leukocytes, neutrophils, and monocytes were negatively correlated with arterial pH levels (r = -0.515, r = -0.510, r = -0.517, all p < 0.001, respectively) and positively correlated with plasma glucose levels (r = 0.722, r = 0.733, r = 0.632, all p < 0.05, respectively) in DKA patients. The arterial pH level was the most significant factor affecting total leukocytes in DKA (β = 0.467, p = 0.003). The diagnosis analysis showed that higher total leukocyte and neutrophil counts and lower eosinophil counts had a significant ability to reflect the presence of hyperglycemic emergencies. Conclusion: More total leukocytes and neutrophils but fewer eosinophils was significantly correlated with DKA and DK. Leukocyte counts can add valuable information to reflect the presence of hyperglycemic crisis and acute infection.
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影响因子：
2
作者：
Karavanaki, Kyriaki;Karanika, Evangelia;Karayianni, Christina
通讯作者：
Karayianni, Christina
DOI：
10.1016/j.bbrc.2004.01.065
发表时间：
2004-03-05
影响因子：
3.1
作者：
Kitabchi, AE;Stentz, FB;Umpierrez, GE
通讯作者：
Umpierrez, GE
影响因子：
3.6
作者：
Faienza MF;Acquafredda A;Tesse R;Luce V;Ventura A;Maggialetti N;Monteduro M;Giordano P;Cavallo L
通讯作者：
Cavallo L
影响因子：
16.2
作者：
Tong, PC;Lee, KF;Chan, JC
通讯作者：
Chan, JC
影响因子：
4.5
作者：
Moradi, Sedigheh;Kerman, Scott Reza Jafarian;Salari, Fereshteh
通讯作者：
Salari, Fereshteh