Lattice-patterned collagen fibers and their dynamics in axolotl skin regeneration.
Lattice-patterned collagen fibers and their dynamics in axolotl skin regeneration.
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DOI：
10.1016/j.isci.2022.104524
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发表时间：
2022-07-15
期刊：
影响因子：
5.8
通讯作者：
Satoh, Akira
中科院分区：
文献类型：
--
作者：
Kashimoto, Rena;Furukawa, Saya;Yamamoto, Sakiya;Kamei, Yasuhiro;Sakamoto, Joe;Nonaka, Shigenori;Watanabe, Tomonobu M.;Sakamoto, Tatsuya;Sakamoto, Hirotaka;Satoh, Akira
真皮中胶原蛋白产生细胞的形态和产生的胶原蛋白的结构尚未得到很好的描述。这种缺乏洞察力一直是皮肤再生评估的严重障碍。我们成功地可视化了胶原蛋白生成细胞，并使用高度透明的美西螈皮肤生产胶原蛋白。可视化的真皮胶原具有网格状结构。产生胶原的成纤维细胞一致地具有网格状的丝状伪足沿着网格状的胶原网络。这种网格状结构的动力学也在蝾螈的皮肤再生过程中得到了验证，发现在简单的皮肤创伤后，正确的网格状结构并没有重组，而是在神经存在的情况下重组。这些发现不仅是皮肤病学的基本见解，也是对皮肤再生机制的宝贵见解。在蝾螈皮肤中观察到由单个细胞合成的真皮胶原蛋白胶原蛋白合成细胞被观察到并显示出网格图案的丝状伪足胶原蛋白图案在简单的皮肤创伤后变形网格图案的胶原蛋白仅在神经存在的情况下是可分解的生理学;动物生理学;生物工程学
The morphology of collagen-producing cells and the structure of produced collagen in the dermis have not been well-described. This lack of insights has been a serious obstacle in the evaluation of skin regeneration. We succeeded in visualizing collagen-producing cells and produced collagen using the axolotl skin, which is highly transparent. The visualized dermal collagen had a lattice-like structure. The collagen-producing fibroblasts consistently possessed the lattice-patterned filopodia along with the lattice-patterned collagen network. The dynamics of this lattice-like structure were also verified in the skin regeneration process of axolotls, and it was found that the correct lattice-like structure was not reorganized after simple skin wounding but was reorganized in the presence of nerves. These findings are not only fundamental insights in dermatology but also valuable insights into the mechanism of skin regeneration. Dermal collagen synthesized by a single cell was visualized in the axolotl skin Collagen-synthetic cells were visualized and revealed lattice-patterned filopodia Collagen pattern was deformed after simple skin wounding The lattice-patterned collagen was only restorable in the presence of nerves Physiology; Animal physiology; Bioengineering
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影响因子：
3.7
作者：
Mitogawa K;Makanae A;Satoh A;Satoh A
通讯作者：
Satoh A
影响因子：
2.7
作者：
Endo, T;Bryant, SV;Gardiner, DM
通讯作者：
Gardiner, DM
影响因子：
3.4
作者：
Tanner, Kandice;Ferris, Donald R.;Gratton, Enrico
通讯作者：
Gratton, Enrico
DOI：
10.1126/science.aaq0681
发表时间：
2018-10-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gerber T;Murawala P;Knapp D;Masselink W;Schuez M;Hermann S;Gac-Santel M;Nowoshilow S;Kageyama J;Khattak S;Currie JD;Camp JG;Tanaka EM;Treutlein B
通讯作者：
Treutlein B
DOI：
10.1002/ar.22529
发表时间：
2012-10-01
影响因子：
2
作者：
Makanae, Aki;Satoh, Akira
通讯作者：
Satoh, Akira