Toxicity of metal-based nanoparticles: Challenges in the nano era.
Toxicity of metal-based nanoparticles: Challenges in the nano era.
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DOI：
10.3389/fbioe.2022.1001572
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发表时间：
2022
影响因子：
5.7
通讯作者：
Liu, Zhenjie
中科院分区：
文献类型：
--
作者：
Zhang, Naiding;Xiong, Guiya;Liu, Zhenjie
关键词：
随着纳米技术的飞速发展，各种纳米粒子在我们的日常生活中得到了广泛的应用。在纳米技术领域，基于金属的纳米颗粒是工程纳米颗粒的重要组成部分，包括金属和金属氧化物纳米颗粒，具有各种生物医学应用。然而，金属基纳米颗粒独特的物理化学性质不仅赋予了良好的生物学效应，同时也对人体造成了意想不到的毒性威胁。为了更安全地将金属基纳米粒子应用于人体，我们应该对纳米粒子的毒性有一个全面的了解。本文综述了金属纳米粒子的毒性、毒性机制、毒性评价、毒性缓解策略以及毒性调控的研究现状。希望在不久的将来，通过相关学科的融合，纳米毒性研究的发展将得到显着促进，从而使金属基纳米粒子在人类中的应用更加安全。
With the rapid progress of nanotechnology, various nanoparticles (NPs) have been applicated in our daily life. In the field of nanotechnology, metal-based NPs are an important component of engineered NPs, including metal and metal oxide NPs, with a variety of biomedical applications. However, the unique physicochemical properties of metal-based NPs confer not only promising biological effects but also pose unexpected toxic threats to human body at the same time. For safer application of metal-based NPs in humans, we should have a comprehensive understanding of NP toxicity. In this review, we summarize our current knowledge about metal-based NPs, including the physicochemical properties affecting their toxicity, mechanisms of their toxicity, their toxicological assessment, the potential strategies to mitigate their toxicity and current status of regulatory movement on their toxicity. Hopefully, in the near future, through the convergence of related disciplines, the development of nanotoxicity research will be significantly promoted, thereby making the application of metal-based NPs in humans much safer.
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影响因子：
3.8
作者：
Ahamed, Maqusood;Karns, Michael;Hong, Yiling
通讯作者：
Hong, Yiling
影响因子：
13.3
作者：
Barbalinardo, Marianna;Caicci, Federico;Gentili, Denis
通讯作者：
Gentili, Denis
影响因子：
13.3
作者：
Andersson, Per Ola;Lejon, Christian;Osterlund, Lars
通讯作者：
Osterlund, Lars
影响因子：
4.1
作者：
Bae, Eunjoo;Park, Hee-Jin;Yi, Jongheop
通讯作者：
Yi, Jongheop
金纳米颗粒的几何形状和表面特征会影响其生物分布和巨噬细胞的吸收。
DOI：
10.1016/j.ejpb.2010.11.010
发表时间：
2011-04
期刊：
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
影响因子：
--
作者：
Arnida;Janát-Amsbury MM;Ray A;Peterson CM;Ghandehari H
通讯作者：
Ghandehari H