Racial Discrimination and White Matter Microstructure in Trauma-Exposed Black Women.
Racial Discrimination and White Matter Microstructure in Trauma-Exposed Black Women.
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DOI：
10.1016/j.biopsych.2021.08.011
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发表时间：
2022-02-01
影响因子：
10.6
通讯作者：
Carter SE
中科院分区：
文献类型：
--
作者：
Fani N;Harnett NG;Bradley B;Mekawi Y;Powers A;Stevens JS;Ressler KJ;Carter SE
种族歧视的经历与一系列负面的大脑健康结果有关，但人们对这些经历如何影响神经结构（包括可能部分介导这些结果的白质微结构）知之甚少。我们的目标是研究美国黑人女性样本中种族歧视经历与白质结构完整性之间的关联。我们招募了 116 名美国黑人女性，作为长期创伤研究的一部分。参与者完成了种族歧视、创伤暴露和创伤后应激障碍（PTSD）的评估，并接受了弥散张量成像（DTI）。从整个大脑的主要白质束中提取分数各向异性 (FA) 和平均扩散率值。种族歧视经历与多个白质束的 FA 显着降低相关，包括胼胝体、扣带回和上纵束 (ps<.004)，即使在考虑了与创伤、PTSD、人口统计和扫描仪相关因素相关的方差后也是如此。这些发现表明，种族歧视的经历与整个大脑白质微结构的减少独立相关。对于经历过其他类型逆境的人来说，种族歧视显然对脑白质结构具有附加且独特的有害影响。我们的研究结果表明种族歧视可能导致美国黑人大脑健康差异的一个途径；种族歧视对主要白质通路微观结构的有害影响可能会增加患神经退行性疾病和心理健康问题的脆弱性。
Experiences of racial discrimination are linked to a range of negative brain health outcomes, but little is known about how these experiences impact neural architecture, including white matter microstructure, which may partially mediate these outcomes. Our goal was to examine associations between racially discriminatory experiences and white matter structural integrity in a sample of Black American women. We recruited 116 Black American women as part of a long-standing study of trauma. Participants completed assessments of racial discrimination, trauma exposure, and posttraumatic stress disorder (PTSD) and underwent diffusion tensor imaging (DTI). Fractional anisotropy (FA) and mean diffusivity values were extracted from major white matter tracts throughout the brain. Experiences of racial discrimination were associated with significantly lower FA in multiple white matter tracts, including the corpus callosum, cingulum, and superior longitudinal fasciculus (ps<.004), even after accounting for variance associated with trauma, PTSD, demographic and scanner-related factors. These findings suggest that experiences of racial discrimination are independently related to decrements in white matter microarchitecture throughout the brain. In individuals who have experienced other types of adversity, racial discrimination clearly has additive and distinctive deleterious effects on white matter structure. Our findings suggest a pathway through which racial discrimination can contribute to brain health disparities in Black Americans; the deleterious contributions of racial discrimination on microstructure of major white matter pathways may increase vulnerability for the development of neurodegenerative disorders as well as mental health problems.
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DOI：
10.1016/j.bbi.2020.07.017
发表时间：
2020-10
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Cuevas AG;Ong AD;Carvalho K;Ho T;Chan SWC;Allen JD;Chen R;Rodgers J;Biba U;Williams DR
通讯作者：
Williams DR
暴露于父母言语虐待的年轻人中白质异常的初步证据。
影响因子：
10.6
作者：
Choi, Jeewook;Jeong, Bumseok;Rohan, Michael L.;Polcari, Ann M.;Teicher, Martin H.
通讯作者：
Teicher, Martin H.
影响因子：
6.6
作者：
Fani, Negar;King, Tricia Z.;Bradley, Bekh
通讯作者：
Bradley, Bekh
影响因子：
3.6
作者：
Fani, Negar;King, Tricia Z.;Jovanovic, Tanja
通讯作者：
Jovanovic, Tanja
影响因子：
3.7
作者：
Asato, M. R.;Terwilliger, R.;Luna, B.
通讯作者：
Luna, B.