Sex-dependent effects of social status on the regulation of arginine-vasopressin (AVP) V1a, oxytocin (OT), and serotonin (5-HT) 1A receptor binding and aggression in Syrian hamsters (Mesocricetus auratus).
Sex-dependent effects of social status on the regulation of arginine-vasopressin (AVP) V1a, oxytocin (OT), and serotonin (5-HT) 1A receptor binding and aggression in Syrian hamsters (Mesocricetus auratus).
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DOI：
10.1016/j.yhbeh.2020.104878
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发表时间：
2021-01
影响因子：
3.5
通讯作者：
Albers HE
中科院分区：
文献类型：
--
作者：
Grieb ZA;Ross AP;McCann KE;Lee S;Welch M;Gomez MG;Norvelle A;Michopoulos V;Huhman KL;Albers HE
仓鼠的优势地位是由精氨酸-加压素V1 a、催产素（OT）和5-羟色胺1A（5-HT 1A）受体之间的相互作用驱动的。下丘脑前部（AH）中V1 a和OT受体的激活增加了男性的攻击性，而降低了女性的攻击性。相反，AH中5-HT 1A受体的激活降低了男性的攻击性，增加了女性的攻击性。这些差异背后的机制尚不清楚。本研究的目的是确定是否优势地位和性别相互作用，以调节V1 a，OT和5-HT 1A受体结合。同性仓鼠（N = 47）在6天内配对12次，每次5分钟。在最后一次相互作用后立即收集配对和未配对（非社会对照）仓鼠的大脑，并使用放射自显影术处理受体结合。V1 a，OT和5-HT 1A受体结合密度的差异在几个大脑区域中观察到作为社会地位和性别的函数。例如，在AH中，存在性别和社会地位之间的相互作用，例如从属男性中的V1 a结合低于从属女性，并且主导男性中的V1 a受体密度高于主导女性。5-HT 1A受体结合也有相互作用，例如，与未配对的对照组相比，社会配对增加了男性AH中的5-HT 1A结合，但降低了女性中的5-HT 1A结合。这些结果表明，支配地位和性别在塑造调节社会行为的神经回路中关键受体亚型的结合特征方面发挥着重要作用。
Dominance status in hamsters is driven by interactions between arginine-vasopressin V1a, oxytocin (OT), and serotonin 1A (5-HT1A) receptors. Activation of V1a and OT receptors in the anterior hypothalamus (AH) increases aggression in males, while decreasing aggression in females. In contrast, activation of 5-HT1A receptors in the AH decreases aggression in males and increases aggression in females. The mechanism underlying these differences is not known. The purpose of this study was to determine if dominance status and sex interact to regulate V1a, OT, and 5-HT1A receptor binding. Same-sex hamsters (N = 47) were paired 12 times across six days in five min sessions. Brains from paired and unpaired (non-social control) hamsters were collected immediately after the last interaction and processed for receptor binding using autoradiography. Differences in V1a, OT, and 5-HT1A receptor binding densities were observed in several brain regions as a function of social status and sex. For example, in the AH, there was an interaction between sex and social status, such that V1a binding in subordinate males was lower than in subordinate females and V1a receptor density in dominant males was higher than in dominant females. There was also an interaction in 5-HT1A receptor binding, such that social pairing increased 5-HT1A binding in the AH of males but decreased 5-HT1A binding in females compared with unpaired controls. These results indicate that dominance status and sex play important roles in shaping the binding profiles of key receptor subtypes across the neural circuitry that regulates social behavior.
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