Human papillomavirus in head and neck squamous cell carcinoma: A descriptive study of histologically confirmed cases at Kamuzu Central Hospital in Lilongwe, Malawi.
Human papillomavirus in head and neck squamous cell carcinoma: A descriptive study of histologically confirmed cases at Kamuzu Central Hospital in Lilongwe, Malawi.
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DOI：
10.4314/mmj.v29i2.12
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Gopal S
中科院分区：
文献类型：
--
作者：
Faggons CE;Mabedi CE;Liomba NG;Funkhouser WK;Chimzimu F;Kampani C;Krysiak R;Msiska N;Shores CG;Gopal S
头颈部鳞状细胞癌(HNSCC)在撒哈拉以南非洲地区很常见，但人类乳头瘤病毒(HPV)的病因学贡献尚未得到很好的证实。我们在马拉维使用p16免疫组织化学(IHC)来评估HNSCC病例中的HPV。研究了p16IHC与肿瘤部位、行为危险因素、人口学特征和HIV状况之间的关系。从2010年到2014年，确诊了77例HNSCC病例。平均年龄52岁，男性50例(65%)，口咽(OP)或口腔(OC)48例(62%)。35名患者(45%)已知艾滋病毒状况，其中5名(14%)为艾滋病毒感染者。已知有40名患者(52%)使用药物，38%的患者报告有烟草，31%的患者报告有酒精。42例(55%)有足够的p16IHC组织，其中7例(17%)阳性，包括22%的OP/OC肿瘤。尽管宫颈癌负担很高，但HPV相关的HNSCC在马拉维并不常见
Head and neck squamous cell carcinoma (HNSCC) is common in sub-Saharan Africa, but the aetiologic contribution of human papillomavirus (HPV) is not well established. We assessed HNSCC cases for HPV using p16 immunohistochemistry (IHC) in Malawi. Associations between p16 IHC and tumour site, behavioural risk factors, demographic characteristics, and HIV status were examined. From 2010 to 2014, 77 HNSCC cases were identified. Mean age was 52 years, 50 cases (65%) were male, and 48 (62%) were in the oropharynx (OP) or oral cavity (OC). HIV status was known for 35 patients (45%), with 5 (14%) HIV-infected. Substance use was known for 40 patients (52%), with 38% reporting any tobacco and 31% any alcohol. Forty-two cases (55%) had adequate tissue for p16 IHC, of which seven (17%) were positive, including 22% of OP/OC tumours. Despite high cervical cancer burden, HPV-associated HNSCC is not very common in Malawi
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DOI：
10.7196/samj.7542
发表时间：
2014-05-01
期刊：
SAMJ: South African Medical Journal
影响因子：
--
作者：
Davidson, C L;Richter, K L;Boy, S C
通讯作者：
Boy, S C
影响因子：
3.7
作者：
Ndiaye C;Alemany L;Diop Y;Ndiaye N;Diémé MJ;Tous S;Klaustermeier JE;Alejo M;Castellsagué X;Bosch FX;Trottier H;Sanjosé Sd
通讯作者：
Sanjosé Sd
影响因子：
45.3
作者：
Chaturvedi, Anil K.;Anderson, William F.;Gillison, Maura L.
通讯作者：
Gillison, Maura L.
影响因子：
45.3
作者：
Chaturvedi, Anil K.;Engels, Eric A.;Gillison, Maura L.
通讯作者：
Gillison, Maura L.
影响因子：
2.1
作者：
Paquette, Cherie;Evans, Mark F.;Cooper, Kumarasen
通讯作者：
Cooper, Kumarasen