A pilot randomized controlled trial of omega-3 fatty acids for autism spectrum disorder.
A pilot randomized controlled trial of omega-3 fatty acids for autism spectrum disorder.
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DOI：
10.1007/s10803-010-1078-8
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发表时间：
2011-05
影响因子：
3.9
通讯作者：
Hendren, Robert L.
中科院分区：
文献类型：
--
作者：
Bent, Stephen;Bertoglio, Kiah;Ashwood, Paul;Bostrom, Alan;Hendren, Robert L.
我们进行了一项随机对照试验，以确定omega-3脂肪酸（1.3 g/天）治疗27名3-8岁自闭症谱系障碍（ASD）儿童多动症的可行性、初步安全性和有效性。12周后，根据异常行为检查表（Aberrant Behavior Checklist）测量，与安慰剂组的0.3（±7.2）分相比，omega-3组的多动性提高了2.7（±4.8）分（p = 0.40；效应值= 0.38）。发现五种脂肪酸水平的降低与多动症的减少之间存在相关性，并且治疗耐受性良好。虽然这项初步研究没有发现omega-3脂肪酸在统计学上的显著益处，但小样本量并不排除小到中等程度的有益效果。
We conducted a pilot randomized controlled trial to determine the feasibility and initial safety and efficacy of omega-3 fatty acids (1.3 g/day) for the treatment of hyperactivity in 27 children ages 3–8 with autism spectrum disorder (ASD). After 12 weeks, hyperactivity, as measured by the Aberrant Behavior Checklist, improved 2.7 (±4.8) points in the omega-3 group compared to 0.3 (±7.2) points in the placebo group (p = 0.40; effect size = 0.38). Correlations were found between decreases in five fatty acid levels and decreases in hyperactivity, and the treatment was well tolerated. Although this pilot study did not find a statistically significant benefit from omega-3 fatty acids, the small sample size does not rule out small to moderate beneficial effects.
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DOI：
10.1097/00001648-199001000-00010
发表时间：
1990-01-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Rothman, K J
通讯作者：
Rothman, K J
DOI：
10.1016/j.plefa.2006.02.001
发表时间：
2006-04-01
影响因子：
3
作者：
Bu, B;Ashwood, P;Jin, LW
通讯作者：
Jin, LW
影响因子：
--
作者：
Amminger, G. Paul;Schafer, Miriam R.;Berger, Gregor E.
通讯作者：
Berger, Gregor E.
影响因子：
3.9
作者：
Lecavalier, Luc
通讯作者：
Lecavalier, Luc
影响因子：
2.8
作者：
Meguid, Nagwa A.;Atta, Hazem M.;Khalil, Rehab O.
通讯作者：
Khalil, Rehab O.