Nonproductive kappa immunoglobulin genes: recombinational abnormalities and other lesions affecting transcription, RNA processing, turnover, and translation
Nonproductive kappa immunoglobulin genes: recombinational abnormalities and other lesions affecting transcription, RNA processing, turnover, and translation
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非生产性 kappa 免疫球蛋白基因：重组异常和其他影响转录、RNA 加工、周转和翻译的病变
DOI：
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发表时间：
1985
影响因子：
5.3
通讯作者：
R. P. Perry
中科院分区：
文献类型：
--
作者：
D. Kelley;L. Wiedemann;A. Pittet;S. Strauss;K. Nelson;J. Davis;B. V. Ness;R. P. Perry
克隆并测序了6个非生产性κ免疫球蛋白基因（κ等位基因）。从序列分析中发现的结构异常与转录、RNA加工、周转和翻译水平的功能性病变相关。四个κ-等位基因，三个含有V κ基因，一个不含，以正常或甚至高于正常的速率转录，这些基因中的缺陷在不同的转录后水平表达。其他两个κ等位基因，这两个都缺乏V基因，表现出极大的抑制，但明显可检测的转录活性。这些结果与增强子和启动子元件之间的分层关系一致，其中增强子在kappa基因座建立转录能力，而启动子（或假启动子）决定转录活性的相对水平。在这项研究中发现的结构异常之一，一个大的缺失，删除整个J κ区，也提供了新的见解VJ和VDJ重组的机制。
Six nonproductive kappa immunoglobulin genes (kappa- alleles) were cloned and sequenced. The structural abnormalities discerned from sequence analysis were correlated with functional lesions at the level of transcription, RNA processing, turnover, and translation. Four kappa- alleles, three containing V kappa genes and one not, are transcribed at normal or even greater than normal rates, the defects in these genes being expressed at various posttranscriptional levels. The other two kappa- alleles, both of which lacked V genes, exhibited greatly depressed yet clearly detectable transcriptional activity. These results are consistent with a hierarchical relationship between enhancer and promoter elements in which the enhancer establishes transcriptional competence at the kappa locus and the promoter (or pseudopromoter) determines the relative level of transcriptional activity. One of the structural abnormalities discovered in this study, a large deletion which removes the entire J kappa region, also provides new insight into the mechanism of VJ and VDJ recombination.
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免疫球蛋白基因“残余”DNA——对抗体基因重组的影响。
影响因子：
14.9
作者：
Selsing,E;Voss,J;Storb,U
通讯作者：
Storb,U
影响因子：
56.9
作者：
EPHRUSSI, A;CHURCH, GM;GILBERT, W
通讯作者：
GILBERT, W
小鼠浆细胞瘤中非免疫球蛋白相关的 DNA 重排。
DOI：
10.1073/pnas.79.13.4175
发表时间：
1982
影响因子：
11.1
作者：
Harris,LJ;Lang,RB;Marcu,KB
通讯作者：
Marcu,KB
DOI：
10.1073/pnas.81.9.2650
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
PARSLOW, TG;BLAIR, DL;GRANNER, DK
通讯作者：
GRANNER, DK