Mutual Interactions between Brain States and Alzheimer's Disease Pathology: A Focus on Gamma and Slow Oscillations.
Mutual Interactions between Brain States and Alzheimer's Disease Pathology: A Focus on Gamma and Slow Oscillations.
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DOI：
10.3390/biology10080707
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发表时间：
2021-07-23
期刊：
影响因子：
4.2
通讯作者：
Sakata S
中科院分区：
文献类型：
--
作者：
Byron N;Semenova A;Sakata S
大脑中的电活动在一天中动态变化。脑活动的异常与包括阿尔茨海默病（AD）在内的各种脑部疾病有关。虽然大脑疾病源于复杂的病理过程，导致神经活动和认知缺陷的异常，但最近的研究表明，控制大脑活动可以改变疾病病理以及认知功能。特别是，在AD小鼠模型中的研究已经提供了关于通过侵入性和非侵入性脑刺激改善AD病理学的有希望的结果。在这篇综述文章中，通过专注于AD，我们提供了这个新兴领域的概述。我们总结了人类和小鼠模型中大脑活动的变化，以及不同的人工操纵大脑活动如何改变AD病理学。虽然进一步的调查是必不可少的，这个研究方向将提供洞察痴呆症的非药物干预策略。大脑的状态每时每刻都在变化。虽然大脑状态可以由正在进行的神经元群体活动（例如神经元振荡）来定义，但这与某些行为或警惕状态紧密相关。近几十年来，大脑状态的异常已被认为是各种大脑疾病和障碍的生物标志物。有趣的是，越来越多的证据也证明了大脑状态和疾病病理之间的相互作用：虽然大脑状态的异常在疾病进展过程中出现，但大脑状态的操纵可以改变疾病病理，这表明了治疗潜力。在这篇综述中，通过关注阿尔茨海默病（AD），最常见的痴呆形式，我们概述了AD患者和小鼠模型的大脑状态如何变化，以及如何控制大脑状态可以修改AD病理。具体而言，我们总结了AD和伽马和慢振荡的变化之间的关系。由于这些振荡中的病理变化与AD病理学相关，因此γ振荡或慢振荡的操作可以改变小鼠模型中的AD病理学。我们认为，神经调节的方法，以目标大脑状态是一个有前途的非药物干预神经退行性疾病。
Electrical activity in the brain dynamically changes throughout the day. Abnormalities in brain activity have been associated with various brain disorders, including Alzheimer’s disease (AD). While brain disorders stem from complex pathological processes, resulting in abnormalities in neural activity and cognitive deficits, recent studies have demonstrated that controlling brain activity can modify disease pathologies as well as cognitive functions. In particular, studies in mouse models of AD have provided promising results regarding the amelioration of AD pathology by invasive and non-invasive brain stimulations. In this review article, by focusing on AD, we provide an overview of this emerging field. We summarise how brain activity changes in humans and mouse models, and how different artificial manipulations of brain activity can modify AD pathology. Although further investigations are essential, this research direction will provide insight into non-pharmacological intervention strategies for dementia. Brain state varies from moment to moment. While brain state can be defined by ongoing neuronal population activity, such as neuronal oscillations, this is tightly coupled with certain behavioural or vigilant states. In recent decades, abnormalities in brain state have been recognised as biomarkers of various brain diseases and disorders. Intriguingly, accumulating evidence also demonstrates mutual interactions between brain states and disease pathologies: while abnormalities in brain state arise during disease progression, manipulations of brain state can modify disease pathology, suggesting a therapeutic potential. In this review, by focusing on Alzheimer’s disease (AD), the most common form of dementia, we provide an overview of how brain states change in AD patients and mouse models, and how controlling brain states can modify AD pathology. Specifically, we summarise the relationship between AD and changes in gamma and slow oscillations. As pathological changes in these oscillations correlate with AD pathology, manipulations of either gamma or slow oscillations can modify AD pathology in mouse models. We argue that neuromodulation approaches to target brain states are a promising non-pharmacological intervention for neurodegenerative diseases.
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