Ultrashort echo time (UTE) magnetic resonance imaging of the short T2 components in white matter of the brain using a clinical 3T scanner.
Ultrashort echo time (UTE) magnetic resonance imaging of the short T2 components in white matter of the brain using a clinical 3T scanner.
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DOI：
10.1016/j.neuroimage.2013.10.053
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发表时间：
2014-02-15
期刊：
影响因子：
5.7
通讯作者：
Bydder GM
中科院分区：
文献类型：
--
作者：
Du J;Ma G;Li S;Carl M;Szeverenyi NM;VandenBerg S;Corey-Bloom J;Bydder GM
大脑白质含有大部分长T2成分和少数短T2成分。使用具有传统回波时间 (TE) 的临床磁共振成像 (MRI) 序列无法检测到这些。在这项研究中，我们使用超短回波时间 (UTE) 序列来研究大脑白质中的超短 T2 成分，并使用临床全身 3T 扫描仪量化其 T2*s 和相对质子密度 (RPD)（相对于质子密度为 100% 的水）。使用绝热反转恢复准备的双回波 UTE (IR-dUTE) 序列对白质中的超短 T2 成分进行形态学成像。以 1000 ms 的恒定 TR 和一系列 TI 进行 IR-dUTE 采集，以确定与第二个回波图像上大脑白质的最小信噪比 (SNR) 相对应的最佳 TI。使用一系列 TE 处 IR-dUTE 信号的单指数衰减拟合来量化超短 T2 分量的 T2*s。通过将超短 T2 组件的 IR-dUTE 信号与橡胶模型的 IR-dUTE 信号进行比较来量化 RPD。对九名健康志愿者进行了研究。 IR-dUTE 序列为大脑白质中的超短 T2 成分提供了出色的图像对比度，在 4.4 分钟的扫描时间内，超短 T2 白质和灰质之间的平均信噪比为 18.7 ± 3.7，对比度为 14.6 ± 2.4，标称体素尺寸为 1.25×1.25×5.0 mm3。健康志愿者大脑白质中 3T 超短 T2 成分的平均 T2* 值为 0.42 ± 0.08 ms，RPD 为 4.05 ± 0.88%。
White matter of the brain contains a majority of long T2 components as well as a minority of short T2 components. These are not detectable using clinical magnetic resonance imaging (MRI) sequences with conventional echo times (TEs). In this study we used ultrashort echo time (UTE) sequences to investigate the ultrashort T2 components in white matter of the brain and quantify their T2*s and relative proton densities (RPDs) (relative to water with a proton density of 100%) using a clinical whole body 3T scanner. An adiabatic inversion recovery prepared dual echo UTE (IR-dUTE) sequence was used for morphological imaging of the ultrashort T2 components in white matter. IR-dUTE acquisitions at a constant TR of 1000 ms and a series of TIs were performed to determine the optimal TI which corresponded to the minimum signal to noise ratio (SNR) in white matter of the brain on the second echo image. T2*s of the ultrashort T2 components were quantified using mono-exponential decay fitting of the IR-dUTE signal at a series of TEs. RPD was quantified by comparing IR-dUTE signal of the ultrashort T2 components with that of a rubber phantom. Nine healthy volunteers were studied. The IR-dUTE sequence provided excellent image contrast for the ultrashort T2 components in white matter of the brain with a mean signal to noise ratio of 18.7 ± 3.7 and a contrast to noise ratio of 14.6 ± 2.4 between the ultrashort T2 white matter and gray matter in a 4.4 min scan time with a nominal voxel size of 1.25×1.25×5.0 mm3. On average a T2* value of 0.42 ± 0.08 ms and a RPD of 4.05 ± 0.88% were demonstrated for the ultrashort T2 components in white matter of the brain of healthy volunteers at 3T.
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影响因子：
4.1
作者：
Biswas, Reni;Bae, Won;Diaz, Eric;Masuda, Koichi;Chung, Christine B.;Bydder, Graeme M.;Du, Jiang
通讯作者：
Du, Jiang
影响因子：
2.5
作者：
MacKay, A;Laule, C;M채dler, B
通讯作者：
M채dler, B
影响因子：
9.9
作者：
Moore, GRW;Leung, E;Paty, DW
通讯作者：
Paty, DW
影响因子：
3.4
作者：
LECAR, H;EHRENSTEIN, G;STILLMAN, I
通讯作者：
STILLMAN, I
影响因子：
19.7
作者：
BREGER, RK;RIMM, AA;HAUGHTON, VM
通讯作者：
HAUGHTON, VM