Exploring the Plasticity of Diet on Gut Microbiota and Its Correlation with Gut Health.

Exploring the Plasticity of Diet on Gut Microbiota and Its Correlation with Gut Health.
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探索饮食对肠道微生物群的可塑性及其与肠道健康的相关性。

DOI:
10.3390/nu15153460
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发表时间:
2023-08-04
期刊:
影响因子:
5.9
通讯作者:
Chen, Shuijiao
Chen, Shuijiao
中科院分区:
医学2区
文献类型:
--
作者:
Yao, Siqi;Zhao, Yiming;Chen, Hao;Sun, Ruizheng;Chen, Liyu;Huang, Jing;Yu, Zheng;Chen, Shuijiao

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Dietary habits have been proven to help alter the composition of gut microbiota, and exploring the impact of nutritional patterns on gut microbiota changes can help protect gut health. However, few studies have focused on the dietary impact on the gut microbiota over an experimental timeframe. In this study, 16S rRNA gene sequencing was employed to investigate the gut microbiota of mice under different dietary patterns, including AIN-93G diet (Control), high protein diet (HPD), high fiber diet (HFD), and switch diet (Switch). The alpha diversity of the HPD group significantly decreased, but HFD can restore this decline. During HPD, some genera were significantly upregulated (e.g., Feacalibaculum) and downregulated (e.g., Parabacteroides). However, after receiving HFD, other genera were upregulated (e.g., Akkermansia) and downregulated (e.g., Lactobacillus). In addition, the interaction between pathogenic bacteria was more pronounced during HPD, while the main effect was probiotics during HFD. In conclusion, the plasticity exhibited by the gut microbiota was subject to dietary influences, wherein disparate dietary regimens hold pivotal significance in upholding the well-being of the host. Therefore, our findings provide new ideas and references for the relationship between diets and gut microbiota.
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